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Some 2,5-Disubstituted-1,3,4-Oxadiazoles. electrolytes incorporation into the beads.
Dhaka Univ. J. Pharm. Sci., 2007, 6 (2), 69-75. Increasing the polymer load decreased the rate and
extent of drug release due to thickness and reduced
1,3,4-Oxadiazoles are important because of its the porosity of the system . Incorporation of mono
versatile biological actions. In the present study, & divalent metal salts by the abating of amount of
several 2.5-disubstituted 1,3,4-oxadiazoles (3a-0) agarose in the formulations increased the release
have been synthesized by the condensation of 4- rate of the drug.
hydroxybenzohydrazide(1) with various aromatic
acids(2a-0) in presence of phosphorus oxychloride. 259 PARVEEN, S. & CHOWDHURY, A.
The structures of the newly synthesized K. A. (Dept. of Clinical Pharmacy and
compounds have been established on the basis of Pharmacology, Dhaka University, Dhaka). In vitro
1
elemental analysis. UV.IR. and H NMR spectral Measurement of Electrolytes and Nutrients
data. The synthesized compounds were screened Transport through Intestinal Epithelium during
for their in vitro growth inhibiting activity against Cholera Toxin Induced Secretion. Dhaka Univ. J.
different strains of bacteria and fungi Viz. Pharm. Sci., 2007, 6 (2), 81-86.
Staphylococcus aureus, Bacillus subtilis, Bacilus
Megaterium, Escherichia Coli, Pseudomonas Cholera toxin and other bacterial toxins can
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aeraginasa, Shigella Dysenteriae, Candida induce electrogenic chloride (Cl ) secretion in
albicans, Aspergillus niger and aspegillus flavus the small intestine resulting in secretory
and the results were compared with the standard diarrhoea, when the colonic water reabsorption
antibioties such as Chloramphenicol (50µg/ml) and capacity is overwhelmed. The mechanism
Griseofulvin (50µg/ml) using agar diffusion underlying this phenomena is that, these toxins
technique. Compounds 3b, 3e, 3h, 3j, 3n exhibited increase intracellular cGMP and/or cAMP level
strong anticterial activity and compounds 3b, through activation of guanylyl and adenylyl
3e,3g, 3h, 3j, 3m and 3n exhibited strong cyclase leading to the phosphorylation of the
antibacterial actively and compounds 3a, 3d, 3g, 3h apical chloride channel (CFTR) and
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and 3i showed good antifugal activity. electrogenic Cl secretion as revealed in vitro by
an increase in short-circuit current reflecting an
258 NIMMI, I.; CHOWDHURY, J.A. increase in electrolyte transport in the intestine.
(Dept. of Pharmacy, Asia Pacific University, The aim of the study was to investigate the
Dhaka); DULAL,M.M. (Julphar Gulf effects of D- (+) glucose on water and
Pharmaceutical Ltd., UAE) & REZA, M.S. electrolyte movements across rat jejunum after
(Faculty of Pharmacy, Dhaka University, challenging with cholera toxin and dbcAMP (a
Dhaka). Effect of Electrolytes on Release of lipophilic analog of cAMP which readily
Diclofenac Sodium from Agarose Beads. crosses the basolateral membrane of small
intestinal cells); and also to investigate whether
Dhaka Univ. J. Pharm. Sci., 2005, 4 (2), 117- the magnitade of response to D-(+) glucose was
120. related to the extent of secretion induced by
dbcAMP. The measurement of the ion transport
Dictofenac sodium loaded agarose heads were across the unstripped rat jejunum was carried
prepared and release profile of Dictofenac Sodium out using Ussing chambers. The response to D-
was investigated. Beads were prepared by (+) glucose was studied in both CT-treated and
dropping a hot aqueous agar solution into a beaker untreated tissue, the results showed no
of chilled Paraffin oil and water. Water made significant difference between Isc responses to
acidic to the pH of 1.65 using concentrated D-(+) glucose in unstimulated and CT-
hydrochloric acid to reduce the prior diffusion of stimulated rat jejunum (∆lsc = 45.3 ± 12.9
Diclotfenac sodium into preparatory vehicle. Upon µA/cm versus 38.9 ± 13.9 µA/cm , n = 8),
2
2
drying, the beads shrank and their dimensions were whereas, in the studies where tissues treated
changed. In-vitro drug dissolution studies were with dbcAMP instead of CT, results showed a
carried out in distilled water. The release profile small but significant difference in D-(+) glucose
was found to be a function of polymer load and
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