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Chemistry, Dhaka University, Dhaka) & RASHID, dissolved in the gastric fluid. Xanthun gum, Na-
M.A. (Centre for Biomedical Research, Dhaka CMC and HPMC based formulation showed nearly
University, Dhaka). In vitro Antimicrobial Activity zero-order release. On the contrary, gelatin and
of Some Synthetic Isoindolinone and PVP K-30 based formulation showed a burst
Isoquinolinone Derivatives. Dhaka Univ. J. release within one hour of dissolution.
Pharm. Sci., 2006, 5 (1-2), 15-19.
273 SHOEB, M.; MAMUN, M.I.R.; NAHAR,
A total of six N-substituted benzamides, eight N. & MOSIHUZZAMAN, M. (Dept. of
isoindolinone derivatives and six isoquinolinone Chemistry, Dhaka University, Dhaka). Biological
analogs have been screened against five Gram Screening of Zizyphus rugosa and Zizyphus
positive and twelve Gram negative bacteria as well oenoplia extractives. Dhaka Univ. J. Pharm. Sci.,
as four human fungal pathogens. From the 2005, 4 (2), 131-134.
antimicrobial screening, it is evident that 2-iodo N-
substituted tetrahydro-l-oxo isoquinoline-3- Different extracts of the leaves and barks of
carboxylic acids showed very prominent activity at Zizyphus rugosa and Zizyphus oenoplia were
a concentration 200 µg/disc, while the N- studied for their antibacterial, antifungal, and β-
substituted-3-alkyl isoindolin-l-one acetates glucuronidase inhibitory activities. The methanol
showed weak to moderate activity. At the same extract of Z. rugosa bark showed significant
time, 2-iodo- N-subustituted benzamides revealed antibacterial activity against Streptococcus
very poor activity. pyogens, Staphylococcus aureus and Pseudomonas
aerogenes whereas the methanol extract of leaves
272 SHAMSUDDIN, M.; AKTER, P. (Dept. of demonstrated moderate activity against Salmonella
Pharmacy, Asia Pacific University, Dhaka); typhi. The chloroform and methanol extracts of Z.
KHAN, M.Z.R.; CHOWDHURY, J.A. & oenoplia showed good activity against a few
REZA, M.S. ( Faculty of Pharmacy, Dhaka bacteria strains. The chloroform extracts of the
University, Dhaka). Studies on Bio-adhesion of barks and leaves of Z. rugosa also showed
Matrix Tablets: I. Release Profile of Theophylline antifungal activity. The methanol and ethyl acetate
Anhydrous. Dhaka Univ. J. Pharm. Sci., 2006, 5 extracts of the brak of Z. rugosa revealed
(1-2), 33-37. significant β-glucuronidase inhibitory activity.
Lupeol, Betuline, betulinaldehyde and betulinic
Controlled release matrix tablets of theophylline acid, isolated from Z. rugosa, also showed good
anhydrous were designed with different types of activity against a few bacteria.
bioadhesive polymers. HPMC 15 cps and 50 cps,
Na-CMC, Gelatin, Xanthun gum and PVP K-30 274 SIRAJ, S.; MAZUMDER, M.E.H.;
were selected to formulate matrix tablets. Tablets MUHSIN, M.D.A. & CHOWDHURY, A.Y.S. F.
of theophylline were prepared by direct U.A. (Dept. of Pharmacy, Jahangirnagar
compression method and were subjected to in vitro University, Savar, Dhaka). Phytopharmacological
drug dissolution for 8 hrs in a gastric fluid media investigation of the petroleum ether extract of
by using thermal shaker with a shaking speed of 50 Uraria lagopodioides DC. stems for anti-
0
rpm at a temperature of 37 ± 0.5 C. The in vitro inflammatory principles. Bang. J. Life Sci., 2007,
release study as well as retention time of 19 (1), 1-6.
bioadhesive tablets on mucous membrane were
investigated to develop a bioadhesive polymer Petroleum ether extract of Uraria lagopodioides
based controlled release delivery system and to DC. stems was studied for anti-inflammatory
evaluate the performance of such delivery device. activity using carrageenan induced acute
Na-CMC, HPMC and Xanthun gum based tablets inflammation in rat hind paw. The extract was
showed greater bio-adhesive strength where as found to be active against acute inflammation and
gelatin and PVP K-30 based tablets showed poor seems to possess more potent anti-inflammatory
bioadhesive strength. Na-CMC and Xanthun gum effect than the classical anti-inflammatory drug
loaded tablets were not discharged from the aspirin. The extract showed a time depended action
nd
mucous membrane and these tablets were fully that reached its peak at the 2 hour after giving the
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