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254 KHATUNE, N.A.; MOSSADIK, comes to dissoliution media easily and water
M.A.; RAHMAN, M.M., KHONDKAR, soluble additives from channel very fast. The
P.;HAQUE, M.E. (Dept. of Pharmacy, Rajshahi Linetics study of the drug was performed and it
University, Rajshahi) & GRAY, A.I. (Dept. of was revealed that the release of drug from peilets
Pharmaceutical Sciences, Strathclyde University, appeared to follow zero order Linetics.
Scotland, UK.). A Benzofuranone from the
flowers of Nyctanthes arbortristis and its 256 MOLLA, M.A.K.; SHAHEEN, S.M.;
Antibacterial and Cytotoxic Activities. Dhaka RASHID, M.& HOSSAIN, A.K.M.M. (Dept.
Univ. J. Pharm. Sci., 2005, 4 (1), 7-10. of Phasmacy, Rajshahi University, Rajshahi). Rate
Controlled Release of Naproxen from HPMC
A benzofuranone, 3, 3a, 7, 7a-tetrahydro-3a- Based Sustaincd Release Dosage From : 1.
hydroxy-6(2H)- benzofuranone (1), was isolated Microcapsule Compressed Tablet and
from the flower of Nyctanthes arbortristis Linn. Matrices. Dhaka Univ. J. Pharm. Sci., 2005, 4
The compound was identified by 1D and 2D NMR (1), 15-21.
and MS analyses. It showed significant
antibacterial activity against both Gram positive The aim of the present study was to investigate the
and Gram negative bacteria. The LC50 of the release kinetic profiles of Naproxen (NP) from
compound was found to be 8.73 µg/ml in brine microcapsule compressed as well as matrix tablets
shrimp lethality bioassay. using a combination of water insoluble materials
with hydrophilic polymers. The ethyl cellulose
255 KIBRIA, G. & JALIL, R. (Dept. of (EC)/, hydroxyl propyl methyl cellulose (HPMC)
Pharmaceutical Technology, Dhaka University, combination controlled the release rate of NP by
Dhaka). In Vitro Release Kinetics Study of their concentration ratios from the microcapsule
Diltiazem Hydrochloride from Pellets using an compressed tablets. When the hydrophilic part of
Ethylcellulose Pseudolatex Coating System. the combination was increased, the release rate of
Dhaka Univ. J. Pharm. Sci., 2007, 6 (2), 87-92. NP was rationally increased. Accordingly their
kinetic constants as well as dieffusion coefficients
In the present study an attempt has been made to also increased. It can be concluded that the
investigate the effect of ethylcellulose as a rate hydrophilic part HPMC could contribute a
retarding material to sustain the release of developed-macromolecular network structure
diltiazem hydrochloride from pellets prepared by along with EC, through which the NP release can
air suspension technique. Aqueous ethylcellulose be controlled like twinning-release system. On the
dispersion (Surelease) with different weight ratios other hand introduction of waxy materials like bees
was chosen to sustain the release of the drug. wax (BW), cetyl alcohol (C-A) and stearic acid
Drug was loaded on dummy seeds by following (SA) into the HPMC based matrices showed a
matrix system us well us barrier coating system. different release pattern. In this case increased
The comparative study of this two manufacturing hydrophobic part of the combinations decreased
processes was also the goal of this study. In vitro the release profiles including kinetic constant as
dissolution studies were carried out using USP well as diffusion coefficient. The first 60% kinetic
dissolution apparatus Type-2. The release of drug profiles showed that tablets using all the additives
was faster from matrix system than that of barrier released the drug by a non-Fickian diffusion
coating system. About 100% drug was released (approx. zero order Model).
within 3 hours with 5% polymer lead from both
systems. While the polymer content was 10%, 257 NAGALAKSHMI, G. (Dept. of
about 4h & 7h required for 50% and 80% drug Pharmaceutical Chemistry, The Erode College of
release respectively from barrier coating system. Pharmacy, Tamilnadu, India). Studies of
The effect of ethylcellulose on the release of Biologically Active Heterocycles: Synthesis,
diliazem hydrochloride was found to be Characterization and Antimicrobial Activity of
predomnant in barrier coating system than that of
the matrix system`. In the matrix system the drug
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