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Crude methanol extracts of leaf and pericarp of were found. Biexponential equation was applied to
Artocarpus (Moraceae) were investigated for
possible cytotoxicity and free radical scavenging
activity. Both extracts exhibited significant
activity in Brine shrimp lethality bioassay. The
LC 50 values were found to be 18.2 µg/ml and
138.9 µg/ml for the extract of leaves and pericarp
respectively. LC 90 values were 482.8 µg/ml and
527.7 µg/ml respectively.The extracts also
showed remarkable antioxidant activity in DPPH
radical scavenging activity and total antioxidant
capacity.In DPPH radical scavenging assay, the
IC50 values of the extracts of pericarp and leaves
were found to be 39.9 µg/ml and 57.9 µg/ml
respectively while, the IC50 value of ascorbic acid
was 12.6 µg/ml. Total antioxidant activity also
increased in a dose dependent manner in both the
cases.
248 HOSSAIN, M.S.; JALIL, R.; REZA,
M.S.; QUADIR, M.A. & HOSSAIN, C.F.
(Faculty of Pharmacy, Dhaka University, Dhaka).
Evaluation of kollicoat SR 30D and Kollicoat
EMM 30D as Matrix Former for Controlled
Release Drug Delivery. Dhaka Univ. J. Pharm.
Sci., 2005, 4 (1), 65-71.
Efficiency of kollicoat EMM 30 D and SR 30D as
matrix forming material was investigated. It was
found that, theophylline loaded granules prepared
with these two polymers could not sustain drug
release for a significant period of time. However,
compression of these granules into tablets
retarded drug release for up to 8 hours. Release
was faster from EMM 30D polymeric system than
that from SR 30D) matrix. Effects of fillers and
rate modifiers on drug liberation have been
assessed. Incorporation of Advice RC 591 and
starch caused substantial release of theophylline
from both the polymeric systems. Advicel PH 101
intensified the retardation effect of both HMM
30D and SR 30D on theophylline release. HPMC
50 cps, when added to the matrix, caused the
release of theophylline to follow near zero order
pattern. Increasing the content of HPMC in both
EMM 30D and SR 30D compressed tablets
decreased the rate and extent of theophylline
release. In the presence of excipients, no
significant differences between role and extent of
drug release from EMM 30D and SR 30D systems
73
explore and explain drug release kinetics. It was
found that drug release followed Fickian or case I
kinetics from EMM 30D compressed tablet while
anomalous or non-fickian kinetics of drug release
was observed for SR 30D system.
249 ISLAM, M.R.; NURNABI, M.;
CHOWDHURY, A.M.S. (Dept. of Applied
Chemistry & Chemical Technology, Dhaka
University, Dhaka), & MASUD, M.M. (Dept.
of Pharmaceutical Chemistry, Dhaka University,
Dhaka). Synthesis of Some Biologically Important
3-Oxacepham Derivatives. Dhaka Univ. J. Pharm.
Sci., 2006, 5 (1-2), 47-51.
The 6H-oxathiazines la-e having imine moiety
underwent [2+2] cycloaddition with
phenoxyacetylchloride in the presence of IC3N to
give β-lactam derivatives 2a-e in high yield. The
X-ray crystallographic analysis revealed the
relative stereochemistry that the substituents at C-2
and C-4 were cis configurated. The subtituents at
C-6 and C-7 were also cis to each other. However,
the 6H-oxathiazines If-i containing tert-butyl or
methyl group at c-4 did not undergo the
cycloaddition.
250 KARIM, P.; SADAT, A.F.M.N.(Dept.
of Pharmacy, Asia Pacific University, Dhaka);
HOSSAIN, M.l.; HASNAT, A. (Dept. of
Clinical Phamacy and Pharmacology, Dhaka
University, Dhaka); QUSAR, M.M.A.S. (Dept.
Of Psychiatry, BSMMU, Dhaka) & ISLAM, S.N.
(Institute of Nutrition and Food Sciences, Dhaka
University, Dhaka). Immunoglobulin (lgG, lgA
and lgM) Profiles in Schizophrenic Patients.
Dhaka Univ. J. Pharm. Sci., 2005. 4 (1), 39-43.
The aim of this study was to determine the
serum immunoglobulin concentration in both
schizophrenic patients and healthy individuals. The
study was conducted with 30 (thirty) schizophrenic
patients (24 males and 6 females, aged 55.4±I3.0
years); age and gender- matched, control subjects
were enrolled. An enzyme-linked immunosorbent
assay (ELISA) was employed to analyze the serum
immunoglobulin concentrations. Results showed
that the concentrations of serum IgG, IgM and IgA