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active. The results are discussed with reference to SULTANA, N. (Analytical Division, BCSIR
the indication of using the plant extracts as an anti- Laboratories, Dhaka).BIOLOGICAL AND
mutagenic agent and appeared to be well-supported CHEMICAL STUDIES ON CALYCOPTERIS
by their chemical constituents. FLORIBUNDA LEAVES. Dhaka Univ. J.
Pharm. Sci., 2005, 4 (2), 103-106.
237 DEWAN, I. (Dept. of Pharmacy, Asia
Pacific University, Dhaka); ELIAS – AL- Dichloromethane subtilis, streptococcus
MAMUN, M. & JALIL, R. (Dept. of pyogen staphyloecus aureus and Sulhmonella
Pharmaceutical Technology, Dhaka University, tyoly The aquerus 90% methanal and 1-buton
Dhaka). IN VITRO RELEASE KINETICS OF of sohulle gractions of the theleayes showed
PROGESTERONE FROM BIODEGRADABLE significant β-glucuronidasc inheletion and
IN SITU IMPLANT SYSTEM. Dhaka Univ. J. antioxidant activity Two pure compounds 3 8
Pharm. Sci., 2007, 6 (2), 99-103. di O methyl ellagic and 2,3,7 di 0- metheyl
ellagic acids were isolated from the 1- butanol
In situ implants containing Progesterone (PRG)
were prepared by using biodegradable Poly (DL- soluble fraction of the present extract.
lactide-co-glycolide) polymer, Dimethyl sulfoxide
(DMSO) was used as an aprotic solvent in this 239 GIRME, A.S.; BHALKE, R.D.;
implant formulation. This system was prepared by GHOGARE, P.B.; TAMBE, V.D.;
dissolving a water insoluble and biodegradable JADHAV, R.S. & NIRMAL, S.A. (Dept. of
polymer (PLGA) in a biocompatible organic Pharmacology, Pravara Rural College of
solvent (DMSO) and then the drug progesterone Pharmacy, India). Comparative In vitro
was added to the polymer solution to produce the Anthelmintic Activity of Mentha Piperita and
drug solution. When the PLGA-PRG solution (0.5 Lantana Camara from Western India. Dhaka Univ.
ml) was injected subcutaneoasly into rat (weight J. Pharm. Sci., 2006, 5 (1-2), 5-7.
130g), the solvent dissipated into the surrounding
tissue leading phase separation and subsequent Methanol extracts from the leaves, stems and roots
coagulation of the polymer & drug to from an of Mentha piperita and Lantana Camara were
implant in situ. The implants were removed from investigated for their anthelmintic activity against
the rat after one hour and stored in freezing Pheritima posthuma. Each extract was studed in
condition. The digital photographs of the in-situ the bioassay at 20 mg/ml. which involed
formed implants obtained after 1 hour shows the determination of time paralysis and time of death
evidence of the formation of the implants. Two of the worms. Both the extracts of both plants
formulations of implants were made. One exhibited considerable anthelmintic activities, and
contained 10% of progesterone and the other 20%. the order of sensitivity of the extracts to the worms
In vitro dissolution studies of progesterone was was stems > roots > leaves > for the M. piperita
performed at static condition in ethanol-water and stems > leaves > roots for the L. camara. The
0
mixture (30.70) at 37 C for 30 days. The impants methanol extracts of stems of both. M. piperita and
of 20% progesterone loading showed about 65% L. camara were found to be the most active.
release and the implants of 10% loading showed Albendazole (20mg/ml) and distilled water were
56% release within 30 days. The release included in the assay as standard reference drug
mechanism from these implants resembles closely and control, respectively.
to Higuchian pattern and first order. The release
rate was found faster from the implants with higher 240 HAQUE, M.A.; HOSSAIN, M.S.;
drug loading of 20% progesterone, compared RAHMAN, M.R.; HOSSAIN, M.S.;
implants of 10% drug loading. MOSIHUZZAMAN, M.; NAHAR, N. (Dept.
of Chemistry, Dhaka University, Dhaka);
238 DEY, S.K.; SHOEB, M.; ROB, T.; RAHMAN, M.Z. & KHAN, S.I. (Dept. of
NAHAR, N.; MOSIHUZZAMAN,M. (Dept. Microbiology, Dhaka University, Dhaka).Isolation
of Chemistry, Dhaka University, Dhaka) &
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