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reference products respectively. For in vitro and in bioequivalent for both the rate and extent of
vivo correlation, level A type was also done for absorption.
both products. In case of level A correlation, a non
linear type of relation was established which is 225 AL-AMIN, M. & ISLAM, M.R. (Dept.
typical for immediate release formulations. of Chemistry, Jahangirnagar University, Savar,
Dhaka). CYTOTOXICITY STUDY OF SOME
224 AKBOR, M.M.; SULTANA, R.; KETONE SCHIFF BASES AND
ULLAH, M.A.; HASNAT, A.(Dept. of HETEROCYCLIC COMPOUNDS, Dhaka Univ.
Clinical Pharmacy and Pharmacology, Dhaka J. Pharm. Sci., 2005, 4 (1), 27-33.
University, Dhaka); AZAD, M.A.K. (Dept. of
Pharmaceutical Technology, Dhaka University, The cytotoxicity of 11 synthesized ketone sohiff
Dhaka) & LATIF, A.H.M.M.; (Institute of bases and 16 heterocyclic compounds was evaluted
Statistical Reseasch and Training, Dhaka by the brine shrimp lethality bioassay. It was
University, Dhaka). PHARMACOKINETIC observed that all the synthesized compounds
showed significant cytotoxic activity with LC 50 of
STUDY OF TWO ORAL FORMULATIONS 1.05-2.45 µg/ml against brine shrimp nauplii.
OF LEVOFLOXACIN IN HEALTHY MALE
VOLUNTEERS. Dhaka Univ.J. Pharm. Sci., 226 ALI, M.S.; ZAMAN, A.; BEGUM, F.;
2006, 5 (1-2), 39-45. ASADUZZAMAN, M.; SAHA, A. & ROUF,
The objective of this study was to compare A.S.S. (Dept. of Clinical Pharmacy and
different pharmacokinetic parameters of a local Pharmacology, Dhaka University, Dhaka).
("X") and reference (Tavanic) formulations of ANALGESIC ACTIVITY OF METHANOL
levofloxacin 250 mg tablets after oral EXTRACT OF MURRAYA KOENIGII L. LEAF.
administration of a single dose under fasting Bang. J. Life. Sci., 2008, 20 (1), 111-115.
condition. Thirteen blood samples were collected
from each of the eight Bangladeshi healthy male The analgesic activity of the methanol extract of
volunteers over 24 hours after oral administration Murraya koenigii Linn, leaf on Swiss albino mice
of the drugs. Serum levofloxacin concentrations was observed by acetic acid induced writing and
were determined by HPLC assay using UV radiant heat tail fcick methods. Per oral
detection, and Pharmacokinetic parameters were administration of the extract at a dose of 500
determined by the non-compartmental method. mg/kg showed significant analgesic activity by
Mean ± SD of C max AUC 0-24, AUC 0-a T max, t 1/2, k et, reduction of percent inhibition of writhing induced
were 4.33 ±1.66 and 4.56 ± 1.51 µg/mL, 45.90 ± by acetic acid (0.5%, w/v) in 47.49% (p< 0,005)
8.74 and 37.77 ±9.94 hr-µg/mL, 79.94 ± 32.80 and and compared with aminopyrine (50 mg/kg).
66.85 ± 35.43 hr-µg/mL, 1.22 ±0.49 and 1.28 Moreover, in radiant heat tail flick method, a
±0.41, 19.90 ± 11.49 and 21.00 ± 16.39 hr, 0.04 ± demonstrable increased in the tail-flick latency
-4
0.02 and 0.05 ± 0.03 hr for the local ("X") and (42.79%; p<0.001) was also observed at oral dose
reference formulation, respectively. From the of 500 mg/kg with respect to morphine (2 mg/kg).
paired t-test, the p-values for two formlations were The obtained results may give a clue for further
found to be 0.182, 0.412 and 0.725 for AUC 0-24, phytochemical analysis of the plant for the
AUC 0-α and C max respectively. The 90% confidence development of natural medicine or searching of
intervals of the mean of the difference between novel analgesic lead molecular armature.
log-transformed values for C max were almost within
the bioequivalence accepted range of 80% to 227 ALIMUZZAMAN, M. & AHMED,
M.
125%, namely: (78.90%, 118.36%); but for AUC 0- (Dept. of Clinical Pharmacy and
24, and AUC 0-α the values were are beyond the Pharmacology, Dhaka University, Dhaka).
acceptable range. (100.83%, 146.52%) and ANALGESIC ACTIVITY OF TRAGIA
(94.34%, 157.89%] respectively The results INVOLUCRATA. Dhaka Univ. J. Pharm. Sci.,
indicate that the two formulations are not 2005, 4 (1), 35-38.
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