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The work was carried out to investigate the ibuprofen and naproxen may be considered as
analgesic activity of the whole plant Tragia safe and effective.
involucrata Linn. The dried whole plant was
successively extracted with petroleum ether, ethyl 229 ASHRAFI, M.; CHOWDHURY, J.A.
acetate and methanol. Expriments were carried out (Dept. of Pharmacy, Asia Pacific University,
with these extracts for their peripheral and central Dhaka) & REZA, M.S. (Faculty of Pharmacy,
antinociceptive potentials on acetic acid induced Dhaka University, Dhaka). CONTROLLED
writhing and radiant heat tail-flick models in mice, RELEASE OF METFORMIN HYDROCHLORIDE
respectively. Both the ethyl acetate and methanolic I. IN VITRO RELEASE FROM PHYSICAL
extracts showed significant writhing inhibition MIXTURE CONTAINING XANTHAN GUM AS
while the elongation of tail-flick time was most HYDROPHILIC RATE RETARDING POLYMER.
prominent with methanolic extract at an oral dose Dhaka Univ. J. Pharm. Sci., 2005, 4 (1), 55-60.
of 500 mg/kg body weight.
Capsules of different formulations were prepared
228 AMRAN, M.S.; BARI, A.H.M.R. by using a hydrophilic polymer, xanthan gum and
(Dept. of Pharmacy, Rajshahi University, a filler Ludipress. Metformin hydrochloride, which
Rajshahi) & HOSSAIN, M.A. (Dept. of is an anti-diabetic agent, was used as a model drug
Pharmaceutical Chemistry, Dhaka University, here with the aim to formulate sustained release
Dhaka). IN VITRO AND IN VIVO capsules. In the first 6 formulations, metformin
INTERACTIONS OF DILTIAZEM WITH hydrochloride and xanthan gum were used in
IBUPROFEN AND NAPROXEN IN AQUEOUS different ratio. Later, Ludipress was added to the
MEDIUM AND RABBITS. Dhaka Univ. J. formulations in a percentage of 8% to 41%. The
Pharm. Sci., 2006, 5 (1-2), 25-28. total procedure was carried out by physical mixing
of the ingredients and filling in capsule shells of
A common practice in the medical science is the size ‘1’. As metformin hydrochloride is a highly
prescription of multiple drugs at a time, which water soluble drug, the dissolution test was done in
may sometimes be neither safe nor effective and 250 ml distilled water in a thermal shaker
may be deleterious. The present study was (Memmert) with a shaking speed of 50 rpm at
0
0
aimed to evaluate such a combination of 37 C ± 0.5 C for 6 hours. After the dissolution, the
diltiazem with ibuprofen and naproxen. The data were treated with different kinetic models.
invitro interaction of diltiazem with ibuprofen The results found from the graphs and data show
and naproxen has been studied at room that the formulations follow the Higuchian release
temperature and at different pH in the aqueous pattern as they showed correlation coefficients
medium by spectroscopic and conductometric greater than 0.99 and the sustaining effect of the
methods, and the invivo study was done in the formulations was very high when the xanthan gum
rabbit by measuring blood pressure using a was used in a very high ratio with the drug. It was
mercury manometer. It has been found that also investigated that the Ludipress extended the
diltiazem formed stable 1 : 1 complexes with sustaining effect of the formulation to some extent.
ibuprofen and naproxen along with some inter But after a certain period, Ludipress did not show
mediates. The Ardon's spectrophotometric any significant effect as the pores made by the
method was employed to confirm the formation xanthan gum network were already blocked. It is
of 1 : 1 complex and for the calculation of the found here that when the metformin hydrochloride
stability constants. The invivo study was carried and the xanthan gum ratio was 1:1, showed a high
out to evaluate the influence of ibuprofen and percentage of drug release, 91.80% of drug was
naproxen on the antihypertensive activity of released after 6 hours. But with a xanthan gum and
diltiazem in the rabbit.Concurrent administration metformin hydrochloride ratio of 6:1, a very slow
of ibuprofen and naproxen with diltiazem did release of the drug was obtained. Only 66.68% of
not make any significant change in the the drug was released after 6 hours. The percent
antihypertensivc activity of diltiazem. It is thus loading in this case was 14%. Again, when
inferred that co-administration of diltiazem with
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