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screening and brine shrimp lethality bioassay. Pentobarbital Narcosis - these four types of
All of the partitionates showed moderate 10 experiment were carried out on Brihat
strong inhibitory activity to microbial growth Purnachandra Rasa (BPR) a classical Ayurvedic
while the chloroform soluble fraction showed tablet preparation. In the gastro-intestinal motility
strongest cytotoxicity having LC5o 1.99 µg/ml. test-using mice, at 15 minute time interval, BPR
showed decrease in gastro-intestinal motility when
compared to the control. Percent traversed by
234 BEPARI, A.K. (Dept. of Pharmacy, North BaS0 4 (15 minute) of the total length decreased in
South University, Dhaka); MAZUMDER, M.E. BPR treated animals but it was not statistically
H.M. & SAHA, P. (Dept of Pharmacy, significant At 30 minute time interval, BPR
Jahangirnagar University, Savar, Dhaka). showed an increase in gastro-intestinal mortility as
COMPARATIVE STUDY OF THE QUALITY was found considering the length traversed. The
OF FOUR AMOXICILLIN CAPSULE BRANDS increase was not found to be statistically
MARKETED IN BANGLADESH IN TERMS OF significant. In the Anti-diarrhoeal Activity Test,
PACKAGING FEATURES, POTENCY AND BPR showed rather poor laxative effect.
DISSOLUTION PROFILE. Bang. J. Life. Sci., Considering the mean number of stools, it was
2006, 18 (1), 91-96. obtained significantly increase at the fourth hour
study period. To check the possible effects of BPR
The present study describes the investigation on on the normal metabolic processes, a 24-hr acute
packaging features, potency and dissolution metabolic study was carried out. BPR has slight
profiles of 4 marketed amoxicillin capsule brands increasing effect on the water intake and urination.
available in Bangladesh. Samples were tested for BPR has slight increasing effect on the food intake
their packaging features as well as their drug but, had no prominent effect on defecation.
content and dissolution profiles on the basis of Pentobarbital sleeping time experiment was carried
USP specifications. Primary packaging of all out to find out whether the formulations had any
samples appeared to have almost similar features effect on the cerebral cortex or not. With increase
with few exceptions. All samples complied with in time of onset and shortening of the duration of
the official specifications for assay and dissolution the sleeping time, BPR might act as an anti-
test. However, one sample was closed to the depressant as revealed from the findings from the
borderline potency and dissolution profiles of all test animals, though none of the effects were
samples were near the minimum limit of official statistically significant.
specification. Correlation test revealed no
significant relationship between the potency and 236 CHOWDHURY, N.S.; KARIM, M.R.
respective dissolution of the samples. & RANA, M.S.(Dept. of Pharmacy,
Jahangirnagar University, Savar, Dhaka). IN
235 BHUIYA, M.S.; KHAN, M.A.M.; VITRO STUDIES ON TOXICOLOGICAL
CHOUDHURI, M.S.K. (Dept. of Pharmacy, PROPERTY OF THE ROOT AND STEM
Jahangirnagar University, Savar, Dhaka); BARK EXTRACTS OF OROXYLUM
SHRESTHA, T. (Nepal Institute of Health INDICUM. Dhaka Univ. J. Pharm. Sci., 2005, 4
Sciences, Purbanchal University, Kathmandu, (1), 51-53.
Nepal); SERAJ, S. & SULTANA, R. (Dept. of
Pharmacy, University of Development Alternative, This research work was carried out to investigate
Dhaka). A STUDY ON THE EFFECTS OF the toxicological activities of the medicinal plant
BRIHAT PURNACHANDRA RASA(BPR) oroxytum indicum using Brine Shimp Lethality in
ON THE GASTRO-INTESTINAL SYSTEM Bioassay. lt was found that the root and stem
AND THE CENTRAL NERVOUS SYSTEM. extracts of the plant contained some constituents
Bang J. Life. Sci 2006, 18 (2), 25-34. that were toxic for the brine shrimp nauplii. The
ether and alcohol extracts may have cytotoxic
Gastro-intestinal Motility test, Antidiarrhoeal properties as well as other pharmacological
Activity test, Acute Metabolic study and activities but the ethyl acetate extract was not so
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