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suggest that hyperhomocysteinemia is a causal
A total of 50 cases were managed and a detailed factor of pre-eclampsia/eclampsia. This study
analysis of these patients was done. Of these ,21 designed to explore the association between
followed hydatidiform mole, 18 after abortion & hyperhomocysteincmia and pre-eclampsia
11 after a term pregnancy. /eclampsia, the knowledge of which expected to be
used for prevention of pre-eclampsia and
Out of 50 cases of gestational trophoblastic eclampsia. In a case-control study serum
tumour, 64% (32 cases) were between 21 and 40 homocysteine was measured in 136 controls
years of age. Eighty six percent (43) presented (healthy pregnant), 84 pre-eclamptic and 120
with per vaginal bleeding while life threatening eclamptic pregnant women. Serum homocysteine
bleeding was occurred in 20% ( 10 cases). Forty in patients with pre-eclampsia (9.54 ± 3.21µ
two percent (21 cases) of patients had hydatidiform mol/L) and eclampsia (10.57 ± 3.39 /µmol/L)
mole and antecedent pg and 36% ( 18 cases) found to be significantly increased compared to
presented within four months of antecedent pg. controls (6.86 ± 2.47 µmol/L)(p<0.001). Between pre-
Blood group 'B' & 'O' were the most frequently eclampsia and eclampsia, homocysteine found to be
encocetled ie 60% (30) and 30% (15 cases). raised more in eclampsia compared to pre-eclampsia
Metastasis was present in 8 (16%) cases of which (p<0.03). In conclusion, hyperhomocysteinemia is
one in medium risk & 7 was in high risk group, site associated with pre-eclampsia as well as
of metastasis was lung and vagina. Serum BHCG eclampsia, but in eclampsia the severity of
of 40,000 min/ml and above was present in 26 homocysteine elevation is more compared to that
(52%) cases. Prior chemotherapy was given in 3 in pre-eclampsia.
patients but they died due to resistance and
complication. Chemotherapy was given to all 314 QUDDUS, S.R. (Sonolab, Center for
patients and survival was 100% in low risk group Diagnostic Uttrasound, 150, Green Road,
and 75% (15 cases) in high risk group. Over all Panthapath Crossing, Dhaka). FETAL HEAD
mortality was 10% ( 5 cases). Major side effects of CIRCUMFERENCE IN BANGLADESH
chemotherapy were stomatities. alopecia, low AND ITS CORRELATION WITH THE
hemoglobin & recurrent infection. WEST. Bang. Med. J., 2006, 35 (2), 54-56.
Late diagnosis, high WHO progastic score & failed
chcmotherapy are the major risk factors affecting Management of fetal head circumference gives a
more accurate assessment of fetal growth than
the outcome. So every patient in reproductive age
group with unexplained per vaginal bleeding measurement of Biparietal diameter, as it is
should be investigated with serum BHCG. independent of head shape. The aim of this study
was to prepare a growth table of fetal head
circumference and to correlate it with a western
313 HOQUE, M.M.; BULBUL, T. (Dept.of study. This is a cross sectional, prospective
Biochemistry, Bangabandhu Sheikh Mujib study. The study population consisted of 672
Medical University, Shahbag, Dhaka); MAHAL, healthy gravid women with accurate menstrual
M. (Dept. of Biochemisty, Dhaka. Medical dates from 14 to 40 weeks menstrual age. The
college, Dhaka,); ISLAM, N. (Dept. of mean head circumference with 2 standard
Biochemistry, North East Medical College, deviations (2SD) for each week was determined.
Sylhet) & FERDAUSI, M. (Dept. of Obstetrics At 14 weeks the HC was found to be 98 mm ±
and Gynecology, Rajshahi Medical College, 10mm (2SD), at 20 weeks it was 172mm
Rajshahi). Serum homocysteine in pre- ±15mm, at 30 weeks it was 276mm ± 22mm, at
eclampsia and eclampsia. Bang. Med. Res. 35 weeks it was 313mm ± 24mm, and at 40
Counc. Bull., 2008, 34 (1,) 16-20. weeks it was 333mm ± 26mm. Whereas in one
of the Hadlock et al's studies performed in 1983,
Pre-eclampsia and eclampsia are common at 14 weeks HC was 98 mm, and at 40 weeks it
obstetrical problem causing adverse effects on was 345 mm. There is a discrepancy of 12 mm
pregnancy outcome. Large bodies of evidences at term between these two studies. Therefore it
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