Page 432 - 16Neonatal Jaundice_compressed

Appendix H: Evidence tables

Bibliographic Study Type & Number of Intervention & Comparison Dichotomous outcomes Continuous Outcomes
Information Evidence Level Patients/Characteristics (E:C) (Mean:SD: N)
Author: Methodology: N: Group 1: Phototherapy failure Mean change in TsB (24 hours)
Sivanandan S RCT 84 Conventional phototherapy Group 1: 52 Group 1: -34 ± 63 micromol/litre
Group 2: 4/42
Year: Blinding: Inclusion: Group 2: Group 2: -39 ± 56 micromol/litre
2009 Not reported Term babies with non- Conventional phototherapy + white
haemolytic jaundice on a curtains ET: Mean duration of phototherapy
Country: Randomisation: postnatal ward of a tertiary level Group 1: 0/10 Group 1: 24.9 ± 15.4 hours
India Not reported but neonatal unit Conventional phototherapy consisted of Group 2: 0/10
sealed opaque Age ≥ 24 hours and < 20 days, Phoenix Medical Systems unit of 4 blue Group 2: 23.3 ± 12.9 hours
192
ID: envelopes use 5 minute Apgar > 6, and 2 white compact fluorescent lamps Mortality:
TSB < 359 micromol/litre 45 cm above the baby. Group 1: 0/10
Evidence level: Group 2: 0/10
1 + Light range was425 – 475 nm
Exclusion:
Hyperbilirubinaemia requiring White plastic sheets could be attached to
exchange transfusion, the sides of the unit
Rh haemolysis,
G6PD deficiency, Treatment failure was defined as TSB
Evidence of haemolysis, > 342 micromol/litre
Positive Coombs’ test,
Major congenital malformation, Phototherapy was discontinued if
Culture-positive sepsis, If started after 72 hours of age after two
Need of intensive care consecutive TSB < 256 micromol/litre
If started before 72 hours of age after
Demographics: two consecutive were less than age-
Gender (M/F): 47/35 specific threshold for phototherapy
Mean GA: 37.5 ± 1.3 weeks TSB was measured for rebound after
Mean BW: 2856 ± 345 g 8 hours
Mean age at entry to study:
69 ± 36 hours
Mean TSB:
280 ± 39 micromol/litre
Author: Methodology: N: All babies received phototherapy which Mean change in TEWL
Grunhagen D Case series 18 consisted of a single quartz spotlight 2.9 ± 3.9 g/m /h
2
(Bililight Ohmeda) 55 cm above the
Year: Blinding: Inclusion: baby. The irradiance was
2002 None Preterm with non-haemolytic 12.5 microwatt/cm² per nm. Light range TEWL retuned to pre-phototherapy levels within 1 hour of
hyperbilirubinaemia was 420 – 480 nm. discontinuation of phototherapy
Country: Randomisation:
Netherlands None Exclusion: TEWL was measured with a Tewameter
None TM210 (YSI Inc) and measurements
ID: Evidence level: taken on chest or back of the baby.
187
3 Demographics:
Gender (M/F): / TEWL was measured when
Mean GA: 30.6 ± 1.6 weeks hyperbilirubinaemia was diagnosed and
60 minutes after initiation of

289