Page 436 - 16Neonatal Jaundice_compressed
P. 436

Appendix H: Evidence tables


              Bibliographic   Study Type &   Number of            Intervention & Comparison   Dichotomous outcomes   Continuous Outcomes
              Information    Evidence Level   Patients/Characteristics                       (E:C)             (Mean:SD: N)
              Year:          Blinding:      Inclusion:            Group 2:
              1986           Not reported   Preterm babies with gestational  Phototherapy with Chest shields   Late mortality
                                            age between 26 and 32 weeks                      Group 1: 4/38
              Country:       Randomisation:                       All babies were receiving early   Group 2: 10/36
              USA            Randomisation chart  Exclusion:      phototherapy to prevent
                                            None                  hyperbilirubinaemia and were nursed
                184
              ID:            Evidence level:                      under radiant warmers, receive
                             1 +            Demographics:         mechanical ventilation for respiratory
                                            Gender (M/F):Not reported   distress syndrome.
                                            Mean GA: 29.4 weeks
                                            Mean BW: 2034 g       Standard phototherapy units (Air
                                            Mean age at entry to study: Not  Shields) were used Mean light intensity
                                            reported              was 4.77 microwatt/cm² per nm
                                            Mean TSB: micromol/litre
                                                                  Chest shields were folded (doubled)
                                                                  piece of aluminium foil covered in a
                                                                  gauze pad and taped over the left chest.
              Author:        Methodology:   N:                    Phototherapy consisted of standard unit      Mean change in Lymphocyte-DNA damage
              Tatli M        Comparative study   47 (14 were healthy controls)   of 4 blue and 2 white fluorescent tubes      PT: 29.1 ± 1.9
                             with healthy controls                (Air Shields) with a light range of 480 –
              Year:                         Inclusion:            520 nm and an irradiance of                  Control: 2.7 ± 2.9
              2008           Blinding:      Term babies with non-  12 microwatt/cm² per nm. Phototherapy
                             None           haemolytic hyperbilirubinaemia
              Country:                                            lasted 72 hours, babies whose TsB
              Turkey         Randomisation:   Exclusion:          declined to normal levels before
                             None           None                  72 hours were excluded.

                178
              ID:
                             Evidence level:   Demographics:
                             2 -            Gender (M/F):29/18
                                            Mean GA: 39.3 ± 0.9 weeks
                                            Mean BW: 3021 ± 450 g
                                            Mean age at entry to study:
                                            113 ± 46 hours
                                            Mean TSB: Not reported
              Author:        Methodology:   N:                                               PT                No increased risk of developing childhood malignant melanoma
              Berg P         Retrospective   150                                             Cases: 0/30       in skin of babies who received phototherapy
                             matched case–control                                            Controls: 11/120
              Year:          study          Inclusion:
              1997                          30 cases of childhood cancer
                             Blinding:      before 20 years of age and 120
              Country:       None           controls
              Sweden
                             Randomisation:   Exclusion:
                180
              ID:            None           None

                             Evidence level:   Demographics:


                                                                                                                                                     291
   431   432   433   434   435   436   437   438   439   440   441