Page 73 - Cardiac testing for coronary artery disease in potential kidney transplant recipients

Sharma 2009 (Continued)

severity of ischaemia was determined by the number of ischaemic segments seen during
dobutamine stress and by the peak wall motion score index.
Echocardiography
• Resting wall motion abnormality

Follow-up Mean follow-up was 2.3 ± 0.7 years (range 0.2 to 3.3 years)

Notes The authors reported that this study population was different from the study results
published in 2005. We were able to create 2 x 2 tables using tabulated results from the
study

Table of Methodological Quality

Item Authors’ judgement Description

Representative spectrum? Yes ESKD patients undergoing cardiac evalua-
All tests tion as part of transplant workup

Acceptable reference standard? Yes Coronary angiography with a reference
All tests standard threshold of ≥ 70% stenosis

Acceptable delay between tests? Unclear Unclear, but likely to be only short delay
All tests between tests.

Partial verification avoided? Yes All participants who underwent the index
All tests test received the reference standard test
Differential verification avoided? Yes This was not an issue in this study. Disease
All tests status (CAD) is diagnosed only through
coronary angiography

Incorporation avoided? Yes This was not an issue in this study. Disease
All tests status (CAD) is diagnosed only through
coronary angiography

Reference standard results blinded? Yes Angiograms were interpreted blindly by
All tests two experienced observers and consensus
was obtained in discordant cases from a
third experienced operator

Index test results blinded? Yes The analysis of conventional and tissue
All tests Doppler imaging stress echo data was per-
formed off-line by two independent, expe-
rienced observers blinded to clinical and
coronary angiography data. Consensus was
obtained in discordant cases from a third
experienced operator

Cardiac testing for coronary artery disease in potential kidney transplant recipients (Review) 71
Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.