Page 77 - Cardiac testing for coronary artery disease in potential kidney transplant recipients

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Vandenberg 1996 (Continued)

◦ failure to increase ejection fraction by at least 5 percentage points (in female
subjects and in those with a resting ejection fraction of > 60%, the failure to increase
ejection fraction was not considered abnormal); or
◦ a new wall motion abnormality with exercise

Follow-up The mean time from thallium scintigraphy to the latest follow-up visit was 35 ± 19
months
Notes

Table of Methodological Quality

Item Authors’ judgement Description

Representative spectrum? Yes Renal failure patients undergoing cardiac
All tests evaluation as part of transplant workup

Acceptable reference standard? Yes Yes, coronary angiography with a reference
All tests standard threshold of ≥75% stenosis

Acceptable delay between tests? Yes Angiography was performed 55 ± 42 days
All tests after thallium scintigraphy in 42 patients
and 50 ± 45 days after exercise radionuclide
ventriculography in 40 patients

Partial veriﬁcation avoided? Yes All participants who received an index test
All tests received the reference standard test

Differential veriﬁcation avoided? Yes This was not an issue in this study. Disease
All tests status (CAD) is diagnosed only through
coronary angiography

Incorporation avoided? Yes This was not an issue in this study. Disease
All tests status (CAD) is diagnosed only through
coronary angiography

Reference standard results blinded? Yes Measurements were made by a single ob-
All tests server without knowledge of the results of
the imaging tests

Index test results blinded? Yes Images were interpreted by the consensus
All tests of two experienced radiologists who were
unaware of the angiography results

Relevant clinical information? Yes Relevant clinical information was provided
All tests regarding the performance and analysis of
both the index and reference tests

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