Page 72 - Cardiac testing for coronary artery disease in potential kidney transplant recipients

Sharma 2005 (Continued)

Incorporation avoided? Yes Disease status (CAD) diagnosed by coro-
All tests nary angiography.

Reference standard results blinded? Yes Angiograms were interpreted by two expe-
All tests rienced, blinded observers with consensus
for disagreement

Index test results blinded? Yes All images were reported offline by two ex-
All tests perienced observers blinded to the rest of
the study

Relevant clinical information? Yes Relevant clinical information was provided
All tests regarding performance and analysis of both
the index and reference tests

Uninterpretable results reported? Yes No results were reported to be uninter-
All tests pretable.

Withdrawals explained? Yes No withdrawals were reported.
All tests

Sharma 2009

Clinical features and settings Clinical features
• ESKD patients undergoing cardiac evaluation as part of transplant workup
Setting
• Ealing Hospital NHS Trust, Middlesex, UK

Participants • Number: 143
• DM: 38%
• Angina pectoris or IHD: 27%
• Hypertension: 92%
• Sex: 64% male
Exclusion criteria
• < 18 years; severe aortic stenosis; unstable angina

Study design Cohort study

Target condition and reference standard(s) Coronary artery stenosis measured by coronary angiography
• CAD defined as presence of ≥ 1 coronary arteries with ≥ 70% diameter stenosis

Index and comparator tests DSE
• Peak systolic velocity measured by tissue Doppler imaging: The percentage of
ischaemic myocardium was calculated from tissue Doppler imaging analysis as the
number of ischaemic segments divided by the number of visualised segments.
• Conventional visual assessment: Semi-quantitative analysis was performed using a
17-segment model. An abnormal response was described by the occurrence under stress
of a new or worsening wall motion abnormality in ≥ 1 left ventricular segment. The

Cardiac testing for coronary artery disease in potential kidney transplant recipients (Review) 70
Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.