Page 70 - Cardiac testing for coronary artery disease in potential kidney transplant recipients

Rosario 2010 (Continued)

Reference standard results blinded? Yes An observer experienced in QCA tech-
All tests nique and who did not participate in the
Multi-detector CT analysis - also blind and
independent

Index test results blinded? Unclear Not reported.
All tests

Relevant clinical information? Yes Relevant clinical information was provided
All tests regarding the performance and analysis of
both the index and reference tests

Uninterpretable results reported? Yes No results were reported to be uninter-
All tests pretable.

Withdrawals explained? Yes No withdrawals were present.
All tests

Sharma 2005

Clinical features and settings Clinical features
• ESKD patients undergoing cardiac evaluation as part of transplant workup
Setting
• St George’s Hospital, London, UK
Participants • Number: 128
• Dialysis: 54%
• Principal cause of ESKD: DM (39 patients)
• DM: 39%
• Angina pectoris or IHD: 42%
• Hypertension: 91%
• Sex: 64% male
Exclusion criteria
• Age < 18 years; severe aortic stenosis; unstable angina; inability to consent.

Study design Cohort study

Target condition and reference standard(s) Coronary artery stenosis measured by coronary angiography
• CAD defined as the presence of ≥ 1 coronary arteries with ≥ 70% diameter
stenosis.

Index and comparator tests • Exercise ECG
◦ Patients had treadmill exercise testing according to standard Bruce protocol
to limiting symptoms. The 12 lead ECG was recorded continuously and the following
documented: exercise time to limiting symptom, maximal ST segment change, Duke
multivariate prognostic score, maximal heart rate, maximal systolic blood pressure,
limiting symptoms. The test was stopped if: limiting symptoms (angina, shortness of
breath, dizziness, lethargy), ST depression > 3 mm, ventricular tachycardia, drop in

Cardiac testing for coronary artery disease in potential kidney transplant recipients (Review) 68
Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.