Page 61 - Cardiac testing for coronary artery disease in potential kidney transplant recipients

Krawczynska 1988

Clinical features and settings Clinical features
• 305 patients with ESKD undergoing cardiac assessment prior to kidney transplant
Setting
• Emory University School of Medicine, Georgia, USA

Participants • Number: 46
• DM: percentage not reported
• Angina pectoris: percentage not reported
• Hypertension: percentage not reported
• Sex: not reported

Study design Cohort study

Target condition and reference standard(s) Coronary artery stenosis measured by coronary angiography
• Criterion for positive test results was ≥ 50% reduction in cross-sectional area.

Index and comparator tests Thalium-201 Cardiac SPECT
• Stress was induced in 200 patients via exercise, 105 with dipyridamole. Reversible
perfusion deficits constituted a positive test.

Follow-up Postoperative data available for outcomes of death and adverse cardiac events

Notes Only available in abstract form (presentation).

Table of Methodological Quality

Item Authors’ judgement Description

Representative spectrum? Yes Prerenal transplant cardiac assessment. 305
All tests ESKD patients waiting kidney transplan-
tation

Acceptable reference standard? Yes Coronary angiography with a reference
All tests standard threshold ≥ 50% stenosis

Acceptable delay between tests? Unclear Likely to be short delay between tests.
All tests
Partial verification avoided? No 38 patients received both coronary angiog-
All tests raphy and stress test

Differential verification avoided? Yes Disease status (CAD) diagnosed by coro-
All tests nary angiography.

Incorporation avoided? Yes Disease status (CAD) diagnosed by coro-
All tests nary angiography.

Reference standard results blinded? Unclear Not stated in abstract.
All tests

Cardiac testing for coronary artery disease in potential kidney transplant recipients (Review) 59
Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.