Page 64 - Cardiac testing for coronary artery disease in potential kidney transplant recipients

Marwick 1990 (Continued)

Target condition and reference standard(s) Coronary artery stenosis measured by coronary angiography
• Each angiogram was independently assessed by a reviewer blinded to
fluorographic results.
• CAD was defined as presence of ≥ 1 coronary arteries with ≥ 70% diameter
stenosis.

Index and comparator tests Dipyridamole SPECT Thallium Imaging
• Images were displayed using a semi-quantitative system with a segmented colour
scale. Scans were interpreted by an experienced observer without knowledge of
catheterisation results, and were classified into groups with normal perfusion, fixed
defect or reversible defect.

Follow-up Follow up over 25 ± 14 months.

Notes
Table of Methodological Quality

Item Authors’ judgement Description
Representative spectrum? Yes ESKD patients undergoing cardiac evalua-
All tests tion as part of transplant workup

Acceptable reference standard? Yes Coronary angiography with a reference
All tests standard threshold of ≥ 70% stenosis

Acceptable delay between tests? Yes Thallium scanning was performed within
All tests a week of coronary angiography

Partial verification avoided? Yes All participants who received an index test
All tests received the reference standard test

Differential verification avoided? Yes Disease status (CAD) diagnosed by coro-
All tests nary angiography.

Incorporation avoided? Yes Disease status (CAD) diagnosed by coro-
All tests nary angiography.

Reference standard results blinded? Yes Author correspondence.
All tests

Index test results blinded? Yes Author correspondence.
All tests

Relevant clinical information? Yes Relevant clinical information was provided
All tests regarding performance and analysis of the
index and reference tests

Cardiac testing for coronary artery disease in potential kidney transplant recipients (Review) 62
Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.