Page 59 - Cardiac testing for coronary artery disease in potential kidney transplant recipients

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Herzog 1999 (Continued)

Uninterpretable results reported? Yes No uninterpretable results were present.
All tests

Withdrawals explained? Yes 55 eligible patients participated; 2 were ex-
All tests cluded for unstable angina before sched-
uled testing; 3 underwent DSE and sub-
sequently declined coronary angiography;
50 patients completed the research proto-
col. 39/50 patients qualiﬁed for DSE by the
prespeciﬁed inclusion criterion of ESKD
secondary to diabetic nephropathy (regard-
less of exercise capacity). The remaining 11
patients were unable to perform treadmill
exercise because of peripheral vascular dis-
ease (4 patients), musculoskeletal disease (4
patients), lung disease (1 patient), and gen-
eralised fatigue (2 patients)

Jassal 2007

Clinical features and settings Clinical features
• Between 2004 and 2006, 30 patients were prospectively evaluated who
underwent both DSE and coronary angiography. This population included 12 patients
(5 male, mean age 59 ± 13 years) referred to rule out CAD with normal kidney
function (Cr < 2.0 mg/dL) and 18 patients (8 male, mean age 55 ± 12 years) with
CKD (Cr > 2.0 mg/dL) on haemodialysis referred for pre-renal transplant workup.
Setting
• Boniface General Hospital, Manitoba, Canada
Participants • Number: 18
• DM: 38%
• Angina pectoris: percentage not reported
• Hypertension: 77%
• Sex: 44% male

Study design Cross sectional study

Target condition and reference standard(s) Coronary artery stenosis measured by coronary angiography
• Criterion for positive test results was ≥ 50% reduction in cross sectional area.

Index and comparator tests DSE
• Beta-adrenergic blocking agents were withdrawn for 24 hours before the study.
• Dobutamine was infused at doses of 5, 10, 20, 30, and 40 mg/kg/min for 3
minutes each. Images were analysed using the standard16-segment model

Follow-up None reported

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