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INDEX

opioid dependence 136–138
prevention studies 243–244
quantitative trait loci (QTL) 129–130
social and cultural aspects 150–151
tobacco dependence 130–132
Global use of psychoactive drugs 4–10
Globus pallidus 23
Glutamate 33–34
Glutamate transporter EAAT2 147
Glutamatergic afferents
in schizophrenia 177, 178–179
ventral tegmental area (VTA) 179

Habit, habituation, defined 56–57
Hallucinogens (see also Cannabis; Ecstasy) 104–106, 109
adaptations to prolonged use 106
behavioural effects 105, 110
mechanism of action 105
tolerance and withdrawal 105–106
Health issues 16–17
Helsinki Declaration 212–216
Heritability
defined 126
dependence 138–139
estimations of 127
Heroin, treatment of heroin dependence 84
Human rights, ethical issues 217–218
Hyoscyamine 104–105
Hypnotics, see Sedatives and hypnotics
Hypothalamus 21–22

ICD-10, substance dependence criteria 13
Illicit drugs, see Psychoactive drugs, classification of use
Imipramine, reduction in cocaine use 182
Immunotherapy, prevention of cocaine use 229–231
Incentive 46–47
Incentive sensitization and dopamine 52–55
acquisition of drug use 55
and drug reward 53–54
psychomotor sensitization 53
and tolerance 54–55
Incentive–motivation 48, 57
Indolealkylamines 104
Informed consent 220
biomedical ethics 220

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Index 257 19.1.2004, 11:52