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INDEX

Desmethylimipramine, reduction in cocaine use 182
Diencephalon 21
Dimethoxy-4-methylamphetamine (DOM) 104
Dimethyltryptamine (DMT) 104
Distributive justice 217, 226
Disulfiram, and alcohol abuse 72–73
DMT, see Dimethyltryptamine
DOM, see Dimethoxy-4-methylamphetamine
Dopamine (see also Nucleus accumbens) 34
cannabinoid binding sites 87
and incentive sensitization 52–55
interactions with cholecystokinin 147
psychostimulant-induced levels in frontal cortex 178
and reinforcement learning 50–52
volatile solvent use 102–103
Dopamine beta hydroxylase (DBH) genotype 144
Dopamine receptors
antagonists 177
DRD1 142
DRD2 142, 174
DRD3 142–143
DRD4 137, 143
DRD5 143
Dopamine transporter 143
Dopaminergic system 141–145
candidate genes for dependence 141–145
dopamine (limbic) pathway 44, 106
Doxepin, placebo in smoking studies 181
Drug immunotherapies, prevention studies 229–231
DSM-IV, substance dependence criteria 14

Ecstasy (MDMA) 96–100, 108
adaptations to prolonged use 100
behavioural effects 99
half-life in plasma 99
mechanism of action 99
tolerance and withdrawal 100
Electroencephalography (EEG) 40
Endocannabinoid system 86
Enkephalins 79
Entactogen, defined 97
Ephedrine, see Amphetamines
Epidemiological research, ethical issues 209–210, 224–225
Ethical issues 209–240, 244–247
animal studies 209, 218–219

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Index 255 19.1.2004, 11:52