Page 410 - 16Neonatal Jaundice_compressed
P. 410

Neonatal jaundice


              Bibliographic   Study Type &   Number of            Intervention & Comparison   Dichotomous outcomes   Continuous Outcomes
              Information    Evidence Level   Patients/Characteristics                       (E:C)             (Mean:SD: N)
                                                                  coverings.
              Author:        Methodology:   N: 88                 Group 1:                   ET:               Mean duration of phototherapy
              Martins B      RCT                                  Conventional Phototherapy   Group 1: 0/44    Group 1: 63.8 ± 37 hours
                                            Inclusion:                                       Group 2: 0/44
              Year:          Blinding:      Need for phototherapy   Group 2:                                   Group 2: 36.8 ± 21 hours
              2007           Not reported   according to birthweight   LED phototherapy      Erythema:
                                                                                             Group 1: 0/44     TSB levels – change
              Country:       Randomisation:   Exclusion:          Conventional phototherapy consisted of  Group 2: 0/44   24 hours
              Brazil         Not reported   Direct bilirubin      a single quartz-halogen lamp, with a         Group 1: -22 ± 25 micromol/litre
                                            > 34 micromol/litre   dichroic reflector, positioned 50cm from  Treatment failure:
                158
              ID:            Evidence level:   Haemolytic jaundice,   the baby and illuminating a circle of   Group 1: 0/44   Group 2: -50 ± 26
                             1 -            Ecchymosis,           18cm diameter.             Group 2: 0/44     micromol/litre
                                            Malformations,        Mean irradiance was
                                                                              2
                                            Congenital infection   21 ± 6microW/cm /nm

                                            Demographics:         LED phototherapy consisted of the
                                            Gender (M/F):58/30    Super LED system positioned 30cm
                                            Mean GA: 33.6 ± 1.9 weeks   from the patient and illuminating an
                                            Mean BW: 1998 ± 541 gms   elliptical area of 38cm x 27cm diameter.
                                            Age at entry to study   Mean irradiance was
                                                                              2
                                            68.1 ± 25.5 hours     37 ± 9microW/cm /nm
                                            Mean TSB:               Phototherapy discontinued when TSB
                                            179 ± 38 micromol/litre   levels decreased 30% from original
                                                                  levels

                                                                  Treatment was considered to have failed
                                                                  if TSB continued to rise and reached a
                                                                  level 30% below TSB levels required
                                                                  for exchange transfusion.

              Author: Ebbesen F   Methodology:   N: 141           Group 1:                   ET:               Mean change in TSB:
                             RCT                                  Blue phototherapy          Group 1: 0/69     Group 1: -78 ± 31 micromol/litre
              Year:                         Inclusion:                                       Group 2: 0/72
              2007           Blinding:      Preterm infants (28 –   Group 2:                                   Group 2: -92 ± 31 micromol/litre
                             Not reported   36.6 weeks),          Turquoise phototherapy
              Country:                      Age > 24 hours,
              Denmark        Randomisation:   No previous phototherapy,
                             Not stated but sealed  Non-haemolytic   Treatment duration was fixed (24 hours)
                160
              ID:            envelopes used   hyperbilirubinaemia
                                                                  Phototherapy consisted of either 8 blue
                             Evidence level:   Exclusion:         fluorescent lamps (20 W, 60 x 3.7cm)
                             1 +            Not reported          41 cm above the baby or 8 turquoise
                                                                  fluorescent lamps (18 W, 60 x 2.6cm)


                                            Demographics:         41 cm above the baby. Distance from
                                            Gender (M/F): 80/61   baby was different to ensure irradiance
                                                                  was identical in both groups
            278
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