Page 404 - 16Neonatal Jaundice_compressed

Appendix H: Evidence tables

Bibliographic Study Type & Number of Intervention & Comparison Dichotomous outcomes Continuous Outcomes
Information Evidence Level Patients/Characteristics (E:C) (Mean:SD: N)
Congenital nonbacterial and was increased if TSB RR = 1.05 (95% CI: 0.90,
infection, > 222 micromol/litre in BW 501 – 750 g 1.22)
Judgement at parents may be or
able to return for final TSB > 256 in BW 751 – 1000 g Neurodevelopmental
assessment at 18 – 22 months impairment
Exchange transfusion was indicated Group 1: 235/902
Demographics: TSB exceeded threshold after 8 hours of Group 2: 275/902
Gender (M/F) : 1013/961 intensive phototherapy RR = 0.86 (95% CI: 0.74,
Mean GA: 26.0 ± 2.0 weeks 0.99)

Mean BW: 777 ± 134 g
Mean age at entry to study: Not
reported
Mean TSB: Not reported for all
babies
Author: Methodology: N: Group 1: Max TSB:
Valdes O RCT 75 Phenobarbital Group 1: 96 ± 57 micromol/litre

Year: Blinding: Inclusion: Group 2: Group 2: 58 ± 52 micromol/litre
1971 Not reported Birthweight < 2500 g Phototherapy Group 3: 63 ± 58 micromol/litre

Country: Randomisation: Exclusion: Group 3: Group 4: 140 ± 53 micromol/litre
USA Not reported Positive Coombs test, Phenobarbital + Phototherapy
ABO incompatibility,
ID: Evidence level: Sepsis Group 4:
146
1 - No treatment
Demographics:
Gender (M/F): Not reported
Mean GA: Not reported
Mean BW: 1766 g
Age at entry to study:
Not reported
Mean TSB: Not reported
Author: Costello S Methodology: N: 44 Group 1: ET: Mean duration of phototherapy
RCT Conventional Phototherapy Group 1: 0/24 Group 1: 44.0 ± 42.8 hours
Year: Inclusion: Group 2: 0/20
1994 Blinding: Gestational age between 27 and Group 2: Group 2: 42.0 ± 39.1 hours
Not reported 36 weeks Fiberoptic phototherapy Treatment failure:
Country: TSB > 125 micromol/litre) Group 1: 3/24
Australia Randomisation: (increased with age (hours) and Conventional phototherapy consisted of Group 2: 1/20 Max TSB:
Lottery method birthweight a standard system of four white and 4 Group 1: 210 ± 58 micromol/litre
156
ID: blue fluorescent lamps 50cm above the
Evidence level: Exclusion: baby with an intensity of Group 2: 198 ± 53 micromol/litre
2
1 + Not reported 8 microW/cm /nm

Demographics: Fiberoptic phototherapy (BiliBlanket)
Gender (M/F): Not reported
with a constant setting of

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