Page 403 - 16Neonatal Jaundice_compressed

Neonatal jaundice

Bibliographic Study Type & Number of Intervention & Comparison Dichotomous outcomes Continuous Outcomes
Information Evidence Level Patients/Characteristics (E:C) (Mean:SD: N)
13 cm. The light range is in the 400 –
550 nm range. Irradiance level was
2
35 microW/cm /nm

If TSB levels increased above
predetermined cut-offs double
phototherapy was started using
conventional phototherapy as above.
Author: Methodology: N: 20 Group 1: ET: Mean duration of phototherapy
Dani C RCT Conventional phototherapy Group 1: 0/10 Group 1: 25.8 ± 3.4 hours
Inclusion: Group 2: 0/10
Year: Blinding: Aged < 3 days, Group 2: Group 2: 24.0 ± 2.5 hours
2001 Not reported Gestational age between 31 and Fiberoptic phototherapy
36 weeks, Mean change in TSB:
Country: Randomisation: Clinically stable, Conventional phototherapy consisted of Group 1: Incomplete data
Italy Not reported but No major congenital a Photo-Therapie 800 Group 2: Incomplete data
sealed envelopes used malformations
155
ID: Fiberoptic phototherapy was an Ohmeda
Evidence level: Exclusion: BiliBlanket which was wrapped around
1 + Non-haemolytic jaundice the baby’s torso.

Demographics: Babies were naked except for eye
Gender (M/F): Not reported patches and were in a supine position.
Mean GA: 34.4 ± 1.2 weeks Phototherapy was initiated when TSB
Mean BW: 2600 ± 382 > 220micromol/litre and discontinued
Age at entry to study when TSB < 170 micromol/litre.
49.5 ± 2.9 hours
Mean TSB:
227 ± 10 micromol/litre
Author: Methodology: N: Group 1: ET: Max TSB:
Morris B RCT 1974 Early Phototherapy – begun when Group 1: 2/990 Group 1: 120 ± 31 micromol/litre
Day 1 – 7 TSB > 85 micromol/litre Group 2: 3/984
Year: Blinding: Inclusion: Day 8 – 14 TSB > 120 micromol/litre Group 2: 168 ± 36 micromol/litre
2008 Single-blind – Birthweight between 5001 and Intensive phototherapy:
outcome assessors 1000 g Group 2: Group 1: 3/990
Country: were unaware of Between 12 and 36 hurs of age Phototherapy at Group 2: 13/984
USA allocation TSB ≥ 137 micromol/litre for BW 501 –
Exclusion: 750 g Mortality:
ID: Randomisation: Terminal condition (Ph < 6.8 or Or Group 1: 209/990
145
Computer-generated persistent bradycardia with 171 micromol/litre for BW 751 – Group 2: 201/984
hypoxaemia for > 2 hours), 1000 g
Evidence level: Previous phototherapy, 18 – 22 months
1 ++ Major congenital anomaly, TSB was measured daily. Mortality
Hydrops fetalis, Group 1: 230/946
2
Severe haemolytic disease, Irradiance was 15 – 40 microW/cm /nm Group 2: 218/944

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