Page 398 - 16Neonatal Jaundice_compressed
P. 398

Neonatal jaundice


              Bibliographic   Study Type &   Number of            Intervention & Comparison   Dichotomous outcomes   Continuous Outcomes
              Information    Evidence Level   Patients/Characteristics                       (E:C)             (Mean:SD: N)
                                                                  consisted of a 10.1 X 15.2 cm pad
                                                                  linked to a 150W quartz halogen lamp.
                                                                  A light filter is placed between the lamp
                                                                  and the fiberoptic bundle to allow only
                                                                  400 – 550 nm range through. Irradiance
                                                                  at skin level was 8 –
                                                                           2
                                                                  10 microW/cm /nm.
                                                                  Baby position was changed from prone
                                                                  to supine and vice versa every 6 hours.

                                                                  Fiberoptic BiliBlanket phototherapy
                                                                  consisted of an 11 X 13 cm pad linked
                                                                  to a 150W tungsten halogen lamp. A
                                                                  light filter is placed between the lamp
                                                                  and the fiberoptic bundle to allow only
                                                                  400 – 550 nm range through. Irradiance
                                                                                      2
                                                                  at skin level was 35microW/cm /nm.
                                                                  Baby position was changed from prone
                                                                  to supine and vice versa every 6 hours.

                                                                  Combined phototherapy consisted of
                                                                  conventional phototherapy as above and
                                                                  the fiberoptic Wallaby system as above.
              Author:        Methodology:   N: 171                Group 1:                   ET:               Mean duration of phototherapy
              Tan K          RCT                                  Conventional Phototherapy   Group 1: 0/44    Group 1: 62.6 ± 24.8 hours
                                            Inclusion:                                       Group 2: 0/42
              Year:          Blinding:      Nonhemolytic jaundice,   Group 2:                Group 3: 0/43     Group 2: 87.0 ± 39.5 hours
              1997           Not reported   TSB > 256 micromol/litre or   Fiberoptic phototherapy - Standard   Group 4: 0/42   Group 3: 82.6 ± 38.3 hours
                                            > 222 micromol/litre before
              Country:       Randomisation:   48 hours,           Group 3:                   Rebound jaundice:   Group 4: 64.8 ± 35.2 hours
              Singapore      Lottery method                       Fiberoptic phototherapy – Large   Group 1: 1/44   :
                                            Exclusion:                                       Group 2: 0/42
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              ID:            Evidence level:   Not reported       Group 4:                   Group 3: 0/43
                             1 +                                  Fiberoptic phototherapy - Double   Group 4: 1/42
                                            Demographics:
                                            Gender (M/F): 96/75                              Treatment failure:
                                            Mean GA: 38.5 ± 1.5 weeks   Conventional phototherapy consisted of  Group 1: 0/44
                                                                  seven overhead daylight fluorescent   Group 2: 4/42
                                            Mean BW: 3114 ± 415 gms   lamps arrange din an arc 35cm above   Group 3: 3/43
                                            Age at entry to study   the baby. The baby was kept unclothed  Group 4: 0/42
                                            96.9 ± 30.9 days      except for eye coverings. Irradiance was
                                                                             2
                                            Mean TSB:             6.73 microW/cm /nm
                                            262 ± 17 micromol/litre
                                                                  The standard fiberoptic (BiliBlanket)
                                                                  phototherapy consisted of a pad, 11 X
                                                                  20 cm (illuminated part was 11 X 13cm)
                                                                  which was used without its sheath and


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