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Cell Signalling Biology Michael J. Berridge Module 2 Cell Signalling Pathways 2 29

Module 2: Table continued
Component Comments
S-CaBP1 A short splice variant of caldendrin
CaBP2 Retina
CaBP3 Retina
CaBP4 Brain and retina
CaBP5 Retina
Calneuron-1 The calneurons act to regulate the trafficking function of PtdIns 4-KIIIα
Calneuron-2 at the Golgi
C2 domain Ca 2 + -binding proteins
Synaptotagmins The Ca 2 + sensors that control exocytosis (Module 4: Figure
Ca 2 + -induced membrane fusion)
Synaptotagmin I
Synaptotagmin II
Synaptotagmin III
Otoferin The Ca 2 + sensors that functions in hair cell transmitter release
Annexins Ca 2 + -dependent phospholipid-binding proteins (Module 4: Figure
annexin structure)
Annexin A1
Annexin A2
Annexin A3
Annexin A4
Annexin A5
Annexin A6
Annexin A7
Annexin A8
Annexin A9
Annexin A10
Annexin A11
Annexin A13
Ca 2 + -SENSITIVE ENZYMES AND PROCESSES
Ca 2 + -regulated enzymes
Ca 2 + -dependent protein kinases (CaMKs)
CaMKI
CaMKII
CaMKIII
CaMKIV
Myosin light chain kinase (MLCK)
Phosphorylase kinase
Ins1,4,5P 3 3-kinase
Proline-rich tyrosine kinase 2 (Pyk2) A Ca 2 + -sensitive tyrosine kinase that functions in osteoclast
podosomes (Module 7: Figure osteoclast podosome)
Lipid kinase
hVps34 See Module 9: Figure target of rapamycin signalling
PKC-α
PKC-βI
PKC-βII
PKC-γ
Phosphodiesterases
Cyclic GMP phosphodiesterase (PDE) Some of the phosphodiesterases are sensitive to Ca 2 + see Module 5:
Table PDE family properties
PDE1A
PDE1B
PDE1C
Adenylyl cyclases (ACs) See Module 2: Table adenylyl cyclases for details of these
Ca 2 + -sensitive enzymes
AC-1
AC-III
AC-VIII
AC-V
AC-VI
Dual oxidases (DUOX1-2) See Module 2: Figure redox signalling components
Nitric oxide synthase (NOS)
Module 2: Figure NO and cyclic GMP signalling
Endothelial NOS (eNOS)
Neural NOS (nNOS)
Ca 2 + -activated proteases
Calpain I
Calpain II
Transcription factors
Nuclear factor of activated T cells (NFAT) Module 4: Figure NFAT activation
NFATc1
NFATc2
NFATc3
NFATc4
Cyclic AMP response element-binding protein (CREB) Module 4: Figure CREB activation
Downstream regulatory element modulator (DREAM)
CREB-binding protein (CBP)

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