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Cell Signalling Biology Michael J. Berridge Module 2 Cell Signalling Pathways 2 28

Module 2: Table continued
Component Comments
Channel regulators
Triadin
Junctin
Sorcin EF-hand protein that can bind to annexin 7
FKBP12 FK506-binding protein 12 kDa
FKBP12.6 FK506-binding protein 12.6 kDa
Phospholamban Module 5: Figure phospholamban mode of action
MICU1 Mitochondrial calcium uptake 1 regulates the mitochondrial uniporter
Ca 2 + BUFFERS
Cytosolic buffers
Calbindin D-28k
Calretinin
Parvalbumin
Endoplasmic reticulum (ER)/sarcoplasmic
reticulum (SR) buffers and chaperones
Calnexin
Calreticulin
Calsequestrin
GRP78 Glucose-regulatory protein of 78 kDa. Also known as BiP
GRP94 Glucose-regulatory protein of 94 kDa. Also known as endoplasmin
Ca 2 + SENSORS
EF-hand Ca 2 + -binding proteins
Calmodulin (CaM) A ubiquitous Ca 2 + sensor
Calcineurin B (CaNB) A sensor that resembles CaM and controls the function of calcineurin
(Module 4: Figure calcineurin)
Troponin C (TnC) The Ca 2 + sensor in striated muscle
Miro Mitochondrial Rho-GTPase functions in mitochondrial motility (Module
5: Figure mitochondrial motility)
DAG kinase α ACa 2 + -sensitive enzyme that phosphorylates diacylglycerol (DAG)
(Module 2: Figure InsP 3 /DAG recycling)
Stromal interaction molecule (STIM) Senses Ca 2 + in the ER lumen (Module 3: Figure STIM-induced Ca 2 +
entry)
Apoptosis-linked gene 2 (ALG-2) A penta-EF-hand protein that may control ER-to-Golgi trafficking
(Module 4: Figure COPII-coated vesicles)
S100 proteins
S100 protein clustered on chromosome 1 S100A1-S100A14 are all clustered on 1q21 (Module 4: Figure S100
phylogenetic tree)
S100A1
S100A2
S100A3
S100A4
S100A5
S100A6
S100A7
S100A8
S100A9
S100A10
S100A11
S100A12
S100A13
S100A14
S100 protein clustered on other chromosomes
S100B
S100C
S100P
Neuronal Ca 2 + sensor proteins (NCS) A family of 14 EF-hand Ca 2 + -binding proteins
NCS-1 Brain and retina
Hippocalcin Restricted to hippocampal neurons
Neurocalcin δ Brain and retina
Recoverin Retina
Visinin-like proteins (VILIPs)
VILIP-1 Brain and retina
VILIP-2 Retina
VILIP-3 Retina and cerebellar Purkinje cells
Guanylyl cyclase-activating proteins (GCAPs) Module 10: Figure phototransduction
GCAP1 Retina
GCAP2 Retina
GCAP3 Retina
Kv-channel-interacting proteins (KChIPs)
KChIP1 Brain
KChIP2 Brain
KChIP3/downstream regulatory element modulator This protein has three names which are currently in use
(DREAM)/calsenilin
KChIP4 Brain
Ca 2 + -binding proteins (CaBPs)
Caldendrin Brain and retina
L-CaBP1 A long splice variant of caldendrin

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