Page 449 - An Evidence Review of Active Surveillance in Men With Localized Prostate Cancer

Appendix Table C3.2. KQ3 multivariable analyses (continued)
Author Factors Data source Duration Analyzed Population WW/AS Methods Results as described in paper
yr sample characteristics definitions
PMI
El-Geneidy 174 Clinical Portland VA; 1993- 175 on WW T1-2 on WW Not Multivariable 1. Age 66-74 vs. >75 yr HR=5.0
2004 all pts dx’d 2000 with T1 or T2 explicitly Cox (CI 1.13, 22.17), P=0.034
15008720 with prostate were provided regression 2. PSA doubling time <3 yr vs. >10
cancer in one analyzed predicts yr HR=2.73 (CI 1.19, 6.24),
period; 187 curative P=0.018
on WW treatment 3. 34%-50% vs. <34% positive
biopsies HR=2.47 (CI 1.14, 5.35),
P=0.022

NS (univariate) : PSA ≥4 vs. <4;
Gleason ≥6 vs. <5; T2 vs. T1;
≥34% positive bx vs. <34% ; PSA
density

Median f/u 3.3 yr (range 0.1-8.6
yr).

C-142