Page 445 - An Evidence Review of Active Surveillance in Men With Localized Prostate Cancer

Appendix Table C3.2. KQ3 multivariable analyses (continued)
Author Factors Data source Duration Analyzed Population WW/AS Methods Results as described in paper
yr sample characteristics definitions
PMI
(CI 1.544, 8.769); P=0.003
- ≥20.1 vs. 0-4.0, HR=6.864 (CI
2.587, 18.202); P<0.001
4. Gleason score at dx,
- 7 vs. 2-6, HR=1.082 (CI 0.570,
2.053); P=0.809
- 8-10 vs. 2-6, HR=1.179 (CI
0.395, 3.515); P=0.7681
5. Disease risk,
- intermediate vs. low, HR=NR;
P=NR
- high vs. low, HR=NR; P=NR
6. Race/ethnicity, Black vs. White,
HR=1.220 (CI 0.451, 3.302);
P=0.695

Cox regression using time-
dependent covariates:
Change in serum PSA vs.
baseline, per unit, HR=1.99 (CI
1.18, 3.35).

Results from models using
changes in stage or PSA before
treatment as time-dependent
covariates were not reported.

Estimates were adjusted for age,
race, PSA at dx, clinical T stage,
total Gleason score.

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