Page 448 - An Evidence Review of Active Surveillance in Men With Localized Prostate Cancer
P. 448

Appendix Table C3.2. KQ3 multivariable analyses (continued)
                                            Author          Factors       Data source      Duration      Analyzed         Population         WW/AS          Methods          Results as described in paper
                                              yr                                                          sample        characteristics  definitions
                                             PMI
                                        El-Geneidy 174    Clinical       Portland VA;      1993-       175 on WW        T1-2 on WW         Not            Multivariable    1. Age 66-74 vs. >75 yr HR=5.0
                                        2004                             all pts dx’d      2000        with T1 or T2                       explicitly     Cox              (CI 1.13, 22.17), P=0.034
                                        15008720                         with prostate                 were                                provided       regression       2. PSA doubling time <3 yr vs. >10
                                                                         cancer in one                 analyzed                                           predicts         yr HR=2.73 (CI 1.19, 6.24),
                                                                         period; 187                                                                      curative         P=0.018
                                                                         on WW                                                                            treatment        3. 34%-50% vs. <34% positive
                                                                                                                                                                           biopsies HR=2.47 (CI 1.14, 5.35),
                                                                                                                                                                           P=0.022

                                                                                                                                                                           NS (univariate) : PSA ≥4 vs. <4;
                                                                                                                                                                           Gleason ≥6 vs. <5; T2 vs. T1;
                                                                                                                                                                           ≥34% positive bx vs. <34% ; PSA
                                                                                                                                                                           density

                                                                                                                                                                           Median f/u 3.3 yr (range 0.1-8.6
                                                                                                                                                                           yr).










































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