Page 323 - An Evidence Review of Active Surveillance in Men With Localized Prostate Cancer

Appendix Table C1.14. Treatment characteristics—changes in treatment patterns over time (continued)
Author Database Treatment 1980- 1985-89 1990-94 1995- 2000-04 2005- Statistical Notes
Year 84 99 10 analysis
PMID
82
Abdollah SEER Observation 13.8% 19.6% 25.0% 24.1% 23.5% “all” P<0.001 Clinically
2011 RT 28.8% 30.7% 32.4% 40.5% 38.1% [chi-square trend localized
20965646 RP 57.4% 49.8% 42.6% 35.5% 38.3% tests for prostate
(1988) (1992) (1997) (2002) (2006) treatments over cancer.
time]
The authors
stated that
they could not
account for
adjuvant or
salvage
therapies,
such as oral
ADT or
palliative
chemotherapy,
due to the
unavailability
of such data in
the SEER
database.
48
Underwood SEER Definitive (1992) (1999) Logistic A cross-table
2004 therapy regression for of odds ratios
15017208 (defined as any trends in for ethnicity
Tx other than definitive Tx: and Tx year
ADT/EM) 1. Racial/ethnic (1992-99) was
disparities provided,
improved with stratified by
time in Hispanic tumor grade
men but less so (well-
in Black men. moderately-
2. In 1992 poorly
Hispanic men differentiated);
with i.e. a 2x3x3
moderately/poorly table. Data
differentiated were not
cancers were available for
less likely to assessing
receive definitive ADT and EM

C-79