Page 326 - An Evidence Review of Active Surveillance in Men With Localized Prostate Cancer
P. 326

Appendix Table C1.14. Treatment characteristics—changes in treatment patterns over time (continued)
                                        Author                Database         Treatment          1980-     1985-89        1990-94        1995-     2000-04      2005-     Statistical          Notes
                                        Year                                                      84                                      99                     10        analysis
                                        PMID
                                                                                                                                                                           p<0.001 for
                                                                                                                                                                           definitive therapy
                                                                                                                                                                           in each yr
                                                                                                                                                                           compared to
                                                                                                                                                                           White men). This
                                                                                                                                                                           disparity was less
                                                                                                                                                                           profound than it
                                                                                                                                                                           had been in 1992
                                                                                                                                                                           (OR 0.56 and
                                                                                                                                                                           0.38,
                                                                                                                                                                           respectively).
                                                   47
                                        Underwood             SEER             ADT/EM                                      (1992)         (1999)                           Logistic             “the utilization
                                        2005                                                                                                                               regression for       of ADT/EM
                                        15612083                                                                                                                           trends in Tx         decreased
                                                                                                                                                                           P<0.001              significantly
                                                                                                                                                                                                over time.”
                                                                                                                                                                                                Additional
                                                                                                                                                                                                information
                                                                                                                                                                                                (1992-99) was
                                                                                                                                                                                                presented in a
                                                                                                                                                                                                figure in the
                                                                                                                                                                                                article. Data
                                                                                                                                                                                                were not
                                                                                                                                                                                                available for
                                                                                                                                                                                                assessing
                                                                                                                                                                                                ADT and EM
                                                                                                                                                                                                separately.
                                                 58
                                        Klabunde              SEER,            RP                                                                                          RP: + 58.5%          White men
                                        1998                  Medicare         RT                                                                                          RT: +39.2%           only
                                        9749657                                Conservative                 (1986)         (1993)                                          Conservative Tx:
                                                                               Tx (not                                                                                     -38.4%
                                                                               radiotherapy or
                                                                               surgery)                                                                                    (change in the
                                                                                                                                                                           proportion of men
                                                                                                                                                                           receiving each Tx
                                                                                                                                                                           over the study
                                                                                                                                                                           period, 1986-93).








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