Page 484 - 16Neonatal Jaundice_compressed

Appendix H: Evidence tables

Bibliographic Study Type & Number of Intervention & Comparison Dichotomous outcomes Continuous Outcomes Comments
Information Evidence Level Patients/Characteristics (E:C) (Mean:SD: N)
Year: 1974 Inclusion: physiological Group 2: 0/34 Group 2: 67 ± 33 hours between groups
Blinding: Not jaundice Group 2: Group 3: 1/31
reported Usual nursery care + Conventional Group 3: 72 ± 31 hours No reason given
Country: New Exclusion: phototherapy Mortality: for mortality
Zealand Randomisation: Not reported Group 1: 2/35 Mean rise to max TSB:
‘allocated in rotation’ Group 3: Group 2: 0/34 Group 1: 80.4 ± 49.6 micromol/litre
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ID: Demographics: Usual nursery care + phototherapy + Group 3: 1/31
Evidence level:2 - Gender (M/F) : 49/51 phenobarbitone (for babies with Group 2: 22.2 ± 29.1 micromol/litre
Mean GA: 34.8 ± 2.7 weeks birthweight ≥ 3kg, 8mg x 3 per day, Group 3: 18.8 ± 29.1 micromol/litre
For babies with birthweight < 3kg,
Mean BW: 2155 ± 632 gms 2mg/kg x 3 per day) Time to max TSB (hours):
Age at entry to study
48.1 ± 14.7 hours Conventional Phototherapy consisted of a Group 1: 51 ± 23 hours
Mean TSB: single bank of eight 30 watt fluorescent Group 2: 14 ± 19 hours
174 ± 40 micromol/litre tubes behind a Perspex screen 50cm Group 3: 13 ± 18 hours
above the baby in a bassinet
Light intensity = 2500 lux
Light band = 441 nm
Baby naked and with eyes covered
No deliberate attempt to sequentially
rotate the baby
Author: Methodology: N: Group 1: Mean duration of Phototherapy 15 babies excluded
Odell G CCT 52 Phototherapy Group 1: 48.1 ± 23.0 hours retrospectively

Year: Blinding: Inclusion: Group 2: Group 2: 37.6 ± 18.0 hours
1983 Not reported Hyperbilirubinaemia Phototherapy + Agar 250mg orally every
requiring phototherapy 8 hours during phototherapy
Country: Randomisation:
USA By patient number Exclusion: Phototherapy initiated at
Not reported 239.4 micromol/litre for term babies and
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ID: Evidence level: 171 micromol/litre for preterm babies
2 - Demographics:
Gender (M/F): 31/21 Phototherapy discontinued
GA: Not reported 188.1 micromol/litre for term babies and
BW:2767 ± 69 g 171 micromol/litre for preterm babies
Mean age at entry to study:
80.6 ± 28.7 hours
Mean TSB:
234 ± 46.8 micromol/litre
Author: Methodology: N: Group 1: Mean decrease in TsB
Ebbesen F CCT 49 Phototherapy Group 1: 87 ± 39 micromol/litre

Year: Blinding: Inclusion: Group 2: Group 2: 85 ± 40 micromol/litre
1977 Not reported Hyperbilirubinaemia Phototherapy + Agar 250mg orally at
requiring phototherapy feedings every three hours Mean duration of Phototherapy

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