Page 375 - 16Neonatal Jaundice_compressed

Neonatal jaundice

Bibliographic details Study type & Patient characteristics Results Reviewers Comments
Evidence level
Turkey transaminase (AST) or alanine transaminase (ALT) Mean peak conjugated bilirubin
130 ± 130 micromol/litre
Ref ID: Exclusion:
121
Not reported Diagnoses in conjugated jaundice
Culture-proven sepsis: 14/42 (35.7%)
Setting: Perinatal hypoxia-ischemia: 7/42 (16.7%)
Neonatal Intensive Care Unit
Blood group incompatibility: 5/42 (11.9%)
Sample Size: 42 Trisomy 21: 3/42 (7.1%)
TPN-associated cholestasis (3/42 (7.1%)
Gender M/F: Not reported Neonatal hepatitis: 2/42 (4.8%)
Mean GA: 37 weeks Metabolic liver disease: 1/42 (2.4%)
Mean BW: Not reported
Ethnicity: Not reported Biliary atresia: 1/42 (2.4%)
Portal venous thrombosis: 1/42 (2.4%) Unknown:
4/42 (9.5%)
Author: Study type: Diagnosis: Prolonged Jaundice Prevalence of prolonged
Sarlik Y Case series Criteria: Jaundiced at day 14 jaundice/hyperbilirubinaemia
Setting: Neonatal Intensive Care Unit 31/381 (8.1%)
Year: Evidence level: 3
2003 Sample Size: 26 Median bilirubin levels
Mean GA: 38 weeks TSB: 246 micromol/litre
Country: Mean BW: 3164 g
Turkey Gender M/F: 15/11 Blood group incompatibility: 7/26 (26.9%)
Ethnicity: Not reported
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Ref ID: Breastfeeding: 96% Breast milk jaundice: 14/26 (53.8%)
Mean age jaundice recognised: 19 days:
Possible Biliary Atresia : 1/26 (3.8%) referred to
Exclusion: Preterm babies pediatric gastroenterology due to direct bilirubin

Inadequate caloric intake: 4/26 (15.4%)

Author: Hannam S Study type: Diagnosis: Prolonged Jaundice Median bilirubin levels G6PD testing done where indicated by
Case series Criteria: jaundiced at day 14 TSB: 179 micromol/litre ethnic background of baby
Year: 2000 Setting: Outpatient Clinical Examination by a
Evidence level: 3 ABO incompatibility: 0/154 (0%) Paediatrician is vital
Country: UK Sample Size: 154 Recommended Investigations in
GA (range): 39(37 – 43) weeks Incidence of G6PD deficiency: prolonged jaundice
Ref ID: BW (range): 3.2 (1.98 – 4.8 kg 3/59 (5.1%)  Total & unconugated
122
Gender M/F: 96/58 bilirubin
Ethnicity: 89 (57%) Caucasian, Infection (UTI): 2/154 (1.3%)  PCV & G6PD level (where
36 (23%) Black, 20 (13%) Asian, 9 (6%) Mediterranean appropriate)
Breastfeeding: 96% Idiopathic: Not reported  Urine microscopy &
Jaundice recognised: Older than 14 days: culture
 Inspection of recent stool
Exclusion: Not reported sample for bile pigmentation

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