Page 379 - 16Neonatal Jaundice_compressed

Neonatal jaundice

Bibliographic Study Type & Number of Intervention & Comparison Dichotomous outcomes Continuous Outcomes
Information Evidence Level Patients/Characteristics (E:C) (Mean:SD: N)

BW > 2500
Gender (M/F): 157/119
Mean GA: Not reported
Mean BW: Not reported
Age at entry to study:
64.8 ± 18.4 hours

Mean TSB: 15.6 ± 2.49
MG/DL

Author: Martinez J Methodology: n: 125 Group 1: ET: TSB levels – change
RCT Continue breastfeeding Group 1: 0/25 Groups 1 + 2
Year: 1993 Inclusion: Group 2: 0/26 48 hours: -27 ± 43 micromol/litre
Blinding: TSB > 291 micromol/litre Group 2: Group 3: 0/38
Country: USA Not reported Discontinue breastfeeding, substitute Group 4: 0/36 Groups 3 + 4
Exclusion: formula feeds
133
ID: Randomisation: Congenital anomalies Treatment failure: 48 hours: -72 ± 380 micromol/litre
Computer-generated Neonatal complications Group 3: Group 1: 6/25
Birthweight below 10 Discontinue breastfeeding, substitute Group 2: 5/26
th
Evidence level: th formula feeds, add Conventional Group 3: 1/38
1 + percentile or above 90 phototherapy Group 4: 5/36
percentile
Venous hematocrit > 65% Group 4:
Significant bruising Continue breastfeeding, add
Large cephalhematoma phototherapy
Haemolytic disease Conventional phototherapy

Demographics: Conventional Phototherapy consisted of
Gender (M/F):70/55 Quartz halide spot unit
Mean GA: 39.2 ± 0.9 weeks Irradiance = 10microW/cm 2
Mean BW: 3404 ± 361gms Light band = 400 – 480 nm
Age at entry to study: Not
reported Babies were naked in a bassinet with
their eyes patched

Mean TSB: Phototherapy discontinued at TSB
306 ± 12 micromol/litre < 231 micromol/litre

262