Page 373 - 16Neonatal Jaundice_compressed

Appendix H: Evidence tables

Bibliographic details Study type & Patient characteristics Results Reviewers Comments
Evidence level
Congestive Heart failure = 5 (3.6%)
Multiple anomalies = 2 (1.3%)
Pyloric Stenosis = 2 (1.3%)
Extreme small for gestational age (possible
Rubella) = 1(0.7%)
Hypothyroid = 1(0.7%)
Choledochal cyst = 1(0.7%)
Slightly high aminotransferase levels (100
U/litre) = 3(2.0%)
Sludge in gallbladder = 1(0.7%)
Author: Study type: Diagnosis: Routine hyperbilirubinaemia tests
Newman T Retrospective chart Hyperbilirubinaemia Direct Bilirubin
review Blood type,
Year: Criteria: Complete blood count,
1990 Evidence level: Birthweight > 2500 g, Differential cell count,
3 Hyperbilirubinaemia Reticulocyte count,
Country: Platelet count,
USA Exclusion: Morph, Urinalysis
Low birthweight
Ref ID: Usefulness of tests
119
Setting: Possible cause of hyperbilirubinaemia identified
Hospital from history, physical exam or routine
haematocrit done at 4 hours
Sample Size: 447 145/447 (32.4%)
Gender M/F: Not reported
Mean GA: Not reported Other diagnosis related to hyperbilirubinaemia no
Mean BW: 3440 ± 485 g made due to routine hyperbil. investigations
Ethnicity: Not reported 13/447 (2.9%)

No specific diagnosis related to
hyperbilirubinaemia:
214/447 (47.8%)

Diagnoses possibly from routine hyperbil
investigations not accompanied by other
diagnoses
58/447 (12.9%)

Diagnoses possibly from routine hyperbil
investigations accompanied by other diagnoses
17/447 (3.8%)
Author: Study type: Diagnosis: Mean age at presentation
Tiker F Retrospective chart Conjugated Hyperbilirubinaemia 240 hours
review
Year: Criteria: Mean peak TsB levels
2006 Evidence level: Direct bilirubin > 15% of total TsB 292 ± 193 micromol/litre
3 Elevation in biliary enzymes (gamma glutamyl
Country: transpeptidase (GGT), alkaline pjosphatse (ALP), asparttate

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