Page 370 - 16Neonatal Jaundice_compressed

Neonatal jaundice

Bibliographic details Study type & Patient characteristics Results Reviewers Comments
Evidence level
Mean GA: 36 ± 4 weeks Bilirubin/Albumin molar ratio
r = 0.75, P < 0.001
Mean BW: 2453 ± 813 g
Ethnicity: Not reported
Author: Study type: Diagnosis: Non-haemolytic jaundice Mean TsB levels Serum albumin levels not taken in 6
De Carvalho W Case series Not reported babies
Criteria:
Year: Evidence level: Mothers who received prenatal care and no previous history Mean free bilirubin
1992 3 of lues and with negative serologic test for syphilis, 11.5 ± 6.0 nmol/litre
Birthweight ≥ 2500 g,
Country: Negative direct Coombs test, 0.0115 ± 0.006 micromol/litre
Brazil Gestational age between 37 and 41 weeks,
< 7 days old, Mean Albumin levels
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Ref ID: no history of neonatal anoxia and Apgar ≥ 8 at 1 and 5 3.33 ± 0.3 g/dl
minutes,
normal infants correlation between free bilirubin and indirect
no administration of substances competing for albumin bilirubin
binding site, 0.69 (P < 0.01)
no phototherapy, exchange transfusion or human albumin

Exclusion: Not reported
Setting: Neonatal service

Sample Size: Not reported
Gender M/F: 25/18
Mean GA: Not reported
Mean BW: Not reported
Ethnicity: Not reported
Author: Study type: Diagnosis: Mean TsB levels Abnormal direct bilirubin = direct
Newman T Retrospective case Jaundice Not reported bilirubin above 95 percentile in each
th
series centre (UCSF = ≥ 39micromol/litre,
Year: Criteria: Mean free bilirubin Stanford = ≥ 17 micromol/litre)
1991 Evidence level: Not reported Not reported
3
Country: Exclusion: Mean Albumin levels
USA None Not reported

118
Ref ID: Setting: Mean B/A ratio
Hospital Not reported

Sample Size: 149 (9 from Stanford) Direct Bilirubin
Gender M/F: Not reported Not reported
Mean GA: Not reported
Mean BW: Not reported Direct bilirubin levels were unexplained in 52% of
Ethnicity: Not reported cases while 24% were laboratory errors. The
remainder were as follows;
Isoimmunisation = 19 (12.7%)
Sepsis or pneumonia = 5 (3.6%)

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