Page 366 - 16Neonatal Jaundice_compressed

Neonatal jaundice

Evidence Table – Assessment Tests
Kernicterus

Bibliographic details Study type & Patient characteristics Results Reviewers Comments
Evidence level
Author: Maisels J Study type: Diagnosis: Kernicterus Mean bilirubin levels
Case series Criteria: Not reported TSB: (Not reported)
Year: 1995 Setting: Not reported ABO incompatibility: 1/14 (7.1%)
Evidence level: 3 Sample Size: 14
Country: USA GA (range): 37 – 42 weeks Rh incompatibility: 0/14 (0 %)
BW (range): Not reported)
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Ref ID: Gender M/F: Not reported Incidence of G6PD deficiency: 3/14 (21.4%)
Ethnicity: Not reported
Breastfeeding: All Infection: 2/14 (14.3%)
Onset of Jaundice: Not reported
Idiopathic: 6/14 (42.8%)
Exclusion: None
Author: Bhutani V Study type: Diagnosis: Kernicterus Mean bilirubin levels Demographc data reported for all
Case series Criteria: Not reported TSB: Not reported cases on Kernicterus Register not just
Year: 2006 Setting: Hospital the sample used here
Evidence level: 3 ABO incompatibility: Not reported
Country: USA Sample Size: 125
GA (range): 35 – 42 weeks Rh incompatibility: Not reported
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Ref ID: BW (range): 2015 – 4730 gms
Gender M/F: Not reported Incidence of G6PD deficiency: 26/125 (20.8%)
Ethnicity: White (58.4%), Black (26.4%), Hispanic (8.8%)
and Asian (6.4%) Infection: Not reported
Breastfeeding: Not reported
Onset of Jaundice: Not reported Idiopathic: 44/125 (35.2%)

Exclusion: None
Author: Ogunlesi T Study type: Diagnosis: Bilirubin Encephalopathy Mean bilirubin levels (unconjugated) Also 2 had mixed ABO/Rh
Case series Criteria: severe jaundice and tone abnormalities, abnormal TSB: 348 ± 113 micromol/litre incompatibilities
Year: 2007 cry and abnormal movements
Evidence level: 3 Setting: Hospital ABO incompatibility: 22/115 (19.2%) 4 had mixed ABO incompatibility and
Country: Nigeria septicaemia
Sample Size: 115
112
Ref ID: GA: 97 (84,3%) were term Rh incompatibility: 7/115 (6.1%)
BW: ≥ 77 (69.9%) > 500 g Incidence of G6PD deficiency: 40/115 (34.8%)
Gender M/F: 88/27
Ethnicity: Not reported Infection: 12/115 (10.4%)
Breastfeeding: Not reported
Onset of Jaundice: Not reported

Exclusion: None

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