Page 368 - 16Neonatal Jaundice_compressed

Appendix H: Evidence tables

Evidence Table – Additional Tests

Bibliographic details Study type & Patient characteristics Results Reviewers Comments
Evidence level
Author: Study type: Inclusion criteria 6 studies included.
Hulzebos C Systematic review Studies of Preterm babies with hyperbilirubinaemia that used Higher B/A ratio was associated with abnormal
the Bilirubin/Albumin ratio to predict BIND ABR in 2 studies, lower IQ at 6 years in one study
Year: Evidence level: 1 and with Kernicterus in one study
++
2008
One study found no difference
Country:
USA One study found that binding capacities
(expressed a B/A molar ratio) were lower in
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Ref ID: babies with kernicterus
Author: Study type: Diagnosis: Jaundice Mean TsB levels
Malik G Case-series 227 ± 80 micromol/litre
Criteria: Not reported
Year: Evidence level:
1986 3 Exclusion: Respiratory distress, Mean free bilirubin
Sepsis, 8.7 ± 5.6 nmol/l
Country: Hypothermia,
India Hypoglycaemia, Mean Albumin levels
Postasphysial seizure, 3.6. ± 0. g/dl
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Ref ID: bleeding diathesis
Mean Bilirubin/Albumin ratio
Setting: Special baby care unit 3.7

Sample Size: 53
Gender M/F: Not reported Mean Molar B/A ratio
0.41
Mean GA: 37.9 ± 2.2 weeks
Mean BW: 2780 ± 620 g correlation between free bilirubin and B-A ratio
0.74 (P < 0.001)
Ethnicity: Not reported
Author: Study type: Diagnosis: Mean TsB levels
Chan G Case series Jaundice Not reported

Year: Evidence level: Criteria: Mean free bilirubin
1980 3 Jaundice Not reported

Country: Exclusion: Mean Albumin levels
Canada Not reported Not reported

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Ref ID: Setting: Mean B/A ratio
Neonatal Intensive Care Unit Not reported

Sample Size: 46 (55 samples used)
Gender M/F: Not reported correlation between free bilirubin and

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