Page 326 - 16Neonatal Jaundice_compressed

Neonatal jaundice

Bibliographic details Study type & Patient characteristics Test, Reference Standard, Results Reviewers Comments
Evidence level Threshold for a positive test

Total paired (TcB-TSB) Day 1–2 (n = 67)
observations = 249 Overestimate = 47.8%
Underestimate = 14.9%
Exclusion: babies receiving phototherapy
or already received exchange transfusion Day 3–4 (n = 103)
Overestimate = 34.0%
Underestimate = 13.6%

Day 5–7 (n = 45)
Overestimate = 20.0%
Underestimate = 28.9%

> 7 day (n = 34)
Overestimate = 17.6%
Underestimate = 35.3%

Chang YH; Study Type: Healthy term and near term babies born TcB using Minolta JM-103 Correlation of TcB levels with lab TSB No exclusion criterion
Diagnostic study in a tertiary hospital. levels (Pearson correlation coefficient, Test & Reference test described
Year: 2006 Three measurements made from the n = 447) adequately
Evidence Level: n = 447 forehead, right and left side of the Test and reference test carried
Country: II mean BW 3185 ± 399.9 g anterior chest wall, and their mean r = 0.83, P < 0.0001 out within one hour
Taiwan taken for data analysis. Blinding – not specified
mean GA 38.6 ± 1.3 weeks Bland Altman analysis for difference
76 Postnatal age: Not reported Reference standard: Laboratory between TSB and TcB
Gender: Males = 51.2% TSB levels within 1 hour of TcB
measurement MD = -17 micromol/litre (95% CI 15.3 to
Prevalence of TSB > 20.4)
255 micromol/litre = 15% (67/447) Diagnostic accuracy calculated for SD = 27.2micromol/litre
detecting TSB > 255 micromol/litre
Exclusion: not defined Diagnostic accuracy of TcB (threshold value
> 200 micromol/litre) for detecting TSB >
255 micromol/litre

Sensitivity: 53/67 (79.1%)
Specificity: 301/380 (79.2%)
PPV: 53/132 (40.1%)
NPV: 301/315 (95.6%)

Rubaltelli FF; Study Type: Term and preterm neonates who TcB using BiliChek from the Correlation of TcB levels with lab TSB Unselected population but
Diagnostic study underwent TSB tests as part of normal forehead and sternum – single levels (Pearson correlation coefficient, exclusion criterion not defined
Year: 2001 care at 6 European Hospitals. measurement taken from each site. n = 210) Test & Reference test described
Evidence Level: adequately
Country: Ib n = 210 with 35 babies from each Reference standard: Laboratory Forehead Test and reference test carried
Europe (multicentre hospital TSB levels within 30 minutes of r = 0.87, P < 0.001 out within one hour
study in UK, Germany, BW: < 2500 g = 16.3% TcB measurement Blinding – yes

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