Page 329 - 16Neonatal Jaundice_compressed

Appendix H: Evidence tables

Bibliographic details Study type & Patient characteristics Test, Reference Standard, Results Reviewers Comments
Evidence level Threshold for a positive test
France, Italy, GA: > 36 week = 80.2% Sternum
Switzerland) Postnatal age: < 48 hours = 16.3% Blood sample also collected for r = 0.85, P < 0.001
Gender: Not reported TSB estimation using HPLC-B
77 technique at the same time Correlation of lab TSB levels with TSB
Ethnicity levels using HPLC-B
White = 66.7% Diagnostic accuracy of TcB (Pearson correlation coefficient, n = 210)
Asian = 14.8% (various thresholds) estimated at
Hispanic = 6.7% various thresholds and plotted on r = 0.93, P < 0.001
Other = 11.9% ROC curve.
Bland Altman analysis for difference
Exclusion: not defined between lab TSB and TcB

Forehead
MD = +2.4 micromol/litre (95% CI -2.4 to
+7.1)
SD = 35.4 micromol/litre

Sternum
MD = -14.8 micromol/litre (95% CI -19.9 to
+9.5)
SD = 38.4 micromol/litre

Diagnostic accuracy of TcB on forehead
(threshold 187 micromol/litre) for detecting
TSB > 222 micromol/litre by HLPC-B

Sensitivity: 93%
Specificity: 73%

Diagnostic accuracy of TcB (threshold
238 micromol/litre) for detecting TSB >
290 micromol/litre by HLPC-B

Sensitivity: 90%
Specificity: 87%

Boo NY; Study Type: Healthy term Malaysian babies with TcB using BiliChek from the Correlation of TcB levels with lab TSB Unselected population
Diagnostic study hyperbilirubinaemia forehead and midpoint of sternum – levels (Pearson correlation coefficient, Test & Reference test described
Year: 2007 number of measurements from each n = 345) adequately
Evidence Level: n = 345 site not specified Test and reference test carried
Country: Ib mean BW: 3056 ± 487 g, Forehead out within one hour
Malaysia median GA 38 weeks Reference standard: Laboratory All babies Blinding – yes
TSB levels within 30 minutes of r = 0.80, P < 0.0001 Data not given for the mean
78 postnatal age: range 9 – 388 TcB measurement Malays: r = 0.79, P < 0.0001 difference and SD from Bland
Gender: Males = 60% Chinese: r = 0.84, P < 0.0001 Altman analysis for TSB – TcB

Ethnicity Diagnostic accuracy of TcB Indians: r = 0.83, P < 0.0001
Malays = 63.8% (various thresholds) calculated for

237