Page 330 - 16Neonatal Jaundice_compressed

Neonatal jaundice

Bibliographic details Study type & Patient characteristics Test, Reference Standard, Results Reviewers Comments
Evidence level Threshold for a positive test
Chinese = 30.7% detecting TSB > 250, > 280, and Sternum
Indians = 5.5%, > 300 micromol/litre All babies
r = 0.86, P < 0.0001
Malays: r = 0.86, P < 0.0001
Prevalence of TSB > Chinese: r = 0.86, P < 0.0001
300 micromol/litre = 27.5% (95/345) Indians: r = 0.94, P < 0.0001

Exclusion: infants who had received Correlation of TcB levels with lab TSB
phototherapy or exchange transfusion, levels depending on the time of
congenital anomalies, measurement
severely ill, (Pearson correlation coefficient, 79% of
foreigners, infants with TSB > 300 had measurement at
those with conjugated > 80 hours)
hyperbilirubinaemia.
At < 80 hours
r = 0.85, P < 0.001

At > 80 hours
r = 0.71, P < 0.001

Diagnostic accuracy of TcB for detecting
TSB > 300 micromol/litre

Forehead (threshold 250 micromol/litre)
Sensitivity: 100%
Specificity: 39.2%

Forehead (threshold 260 micromol/litre)
Sensitivity: 75.8%
Specificity: 84.8%

Sternum (threshold 200 micromol/litre)
Sensitivity: 100%
Specificity: 33.6%

Sternum (threshold 280 micromol/litre)
Sensitivity: 92.6%
Specificity: 84%

Ebbesen F; Study Type: All newborns more than 24 hours old TcB measurement using BiliChek Correlation of TcB levels with lab TSB Unselected population
Diagnostic study who for clinical reasons had their plasma from forehead, sternum, knee and levels (Pearson correlation coefficient, Test & Reference test described
Year: 2002 bilirubin determination during the day, the foot – mean of 5 measurements n = 210) adequately
Evidence Level: except at weekends. from each site taken for data Test and reference test carried
Country: III analysis. Group 1: out within one hour
Denmark Group 1: Both preterm infants Forehead Blinding – not specified
< 35 weeks and sick term and near-term Reference standard: Laboratory r = 0.88, p > 0.05 Data not given for the mean
45 infants in the NICU TSB levels taken concurrently with Sternum difference and SD from Bland

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