Page 324 - 16Neonatal Jaundice_compressed

Appendix H: Evidence tables

Bibliographic details Study type & Patient characteristics Test, Reference Standard, Results Reviewers Comments
Evidence level Threshold for a positive test
Hispanic = 92%
Black = 3% Sensitivity: 52/57 (91.2%)
Asian = 3% Specificity: 34/64 (53.1%)
White = 2% PPV: 52/82 (63.4%)
NPV: 34/39 (87.2%)
Prevalence of TSB >
255 micromol/litre = 47% (57/121)

Exclusion: not defined

Sanpavat S; Study Type: Term and near term clinically healthy TcB using Minolta JM-103 from Correlation of TcB levels with lab TSB Unselected population
Diagnostic study neonates ≥ 36 weeks with visible the forehead levels (Pearson correlation coefficient, Test & Reference test described
Year: 2004 jaundice which necessitated TSB n = 460 observations) adequately
Evidence Level: determination. Mean of three measurements taken Test and reference test carried
Country: II for data analysis. r = 0.80, P < 0.001 out within one hour
Thailand n = 388 Blinding – not specified
mean BW 3117 ± 425 g Reference standard: Laboratory Bland Altman analysis for difference
74 TSB levels within 10–15 minutes between TSB and TcB
mean GA: Not reported of TcB measurement
Postnatal age: range 11 to 216 hours MD = 12 micromol/litre (95% CI 9.4 to
Gender: Males = 57.5% Diagnostic accuracy of TcB 14.5)

Ethnicity (various thresholds) calculated for SD = 27.4micromol/litre

detecting TSB > 170, > 204, > 222
Not reported and > 255 micromol/litre Diagnostic accuracy of TcB (threshold value
> 205 micromol/litre) for detecting TSB >
Prevalence of TSB > 255 micromol/litre
255 micromol/litre = 2.8% (13/460)

Exclusion: babies receiving phototherapy Sensitivity: 13/14 (92.9%)
Specificity: 373/446 (83.6$)
or already received exchange transfusion PPV: 13/86 (15.1%)
NPV: 373/374 (99.7%)

Sanpavat S; Study Type: Clinically healthy preterm babies with TcB using Minolta JM-103 from Correlation of TcB levels with lab TSB Unselected population
Diagnostic study BW > 1000 g and GA < 36 weeks with the forehead levels (Pearson correlation coefficient, Test & Reference test described
Year: 2007 visible jaundice which necessitated TSB n = 249 observations) adequately
Evidence Level: determination. Mean of three measurements taken Test and reference test carried
Country: II for data analysis. r = 0.79, P < 0.0001 out within one hour
Thailand n = 196 Blinding – not specified
Reference standard: Laboratory Bland Altman analysis for difference
75 mean BW 1887 ± 344.4 g TSB levels within 1 hour of TcB between TSB and TcB
mean GA 33.2 ± 1.7 weeks, postnatal measurement
age: 108 ± 77 hours MD = -5.0 micromol/litre (95% CI -1.7 to -
Gender: Males = 55% Percentage of TcB readings which 8.5)
SD = 25.5 micromol/litre
overestimated (TcB > 10% of TSB)
or underestimated (TcB < 10% of
Ethnicity TSB) Comparison of TcB readings with TSB
Not reported
levels at different postnatal ages (n = 249)

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