Page 319 - 16Neonatal Jaundice_compressed

Neonatal jaundice

Bibliographic details Study type & Patient characteristics Test, Reference Standard, Results Reviewers Comments
Evidence level Threshold for a positive test
214 micromol/litre = 31.6% (49/155) PPV: 36/47 (76.6%)
NPV: 95/108 (88.0%)
Exclusion:
preterm infants,
ill newborns,
those requiring phototherapy or exchange
transfusion

Maisels MJ; Study Type: Randomly selected full term White TcB using Minolta JM-102 from Correlation of TcB levels with lab TSB No exclusion criterion
Diagnostic study babies in a well-baby nursery the forehead and the sternum levels (Pearson correlation coefficient) Test & Reference test described
Year: 1982 adequately
Evidence Level: n = 157 Measurements routinely made on At forehead (157 observations) Test and reference test carried
Country: II Mean BW: Not reported the 3rd day except in 11 infants r = 0.93, P < 0.0001 out within one hour
USA Mean GA: Not reported where earlier sampling done Blinding – not specified
Gender: Not reported At mid-sternum (135 observations)
68 Reference standard: Laboratory r = 0.93, P < 0.0001
Ethnicity TSB levels at the same time as TcB
Not reported measured Diagnostic accuracy of TcB (Sternum
threshold value > 23 reflectance units) for
Exclusion: not defined detecting TSB > 221 micromol/litre

Prevalence of TSB > Sensitivity: 4/4 (100%)
221 micromol/litre = 7/157 (4.5%) Specificity: 126/131 (96.2%)
PPV: 4/9 (44.4%)
NPV: 126/126 (100%)

Diagnostic accuracy of TcB (Forehead
threshold value > 24 reflectance units) for
detecting TSB > 221 micromol/litre

Sensitivity: 7/7 (100%)
Specificity: 145/150 (96.7%)
PPV: 7/12 (58.3%)
NPV: 145/145 (100%)

Tsai LT; Study Type: Term healthy babies > 37 weeks and less TcB using Minolta JM-102 Correlation of TcB levels with lab TSB No exclusion criterion
Diagnostic study than 7 days old who had jaundice or TSB levels (Pearson correlation coefficient, Test & Reference test described
Year: 1988 measurement Measurements made at the time of n = 178) adequately
Evidence Level: sampling from 8 sites – forehead, Test and reference test carried
Country: III n = 98 cheek, sternum, abdomen, upper Forehead out within one hour
Taiwan paired observations from each of the 8 back, lower back, palm and sole. r = 0.87, P < 0.001 Blinding – not specified
sites = 178
67 mean BW: Not reported Reference standard: Laboratory Cheek
mean GA: Not reported TSB levels at the same time as TcB r = 0.76, P < 0.001
Gender: Not reported measured
Sternum

232