Page 314 - 16Neonatal Jaundice_compressed

Neonatal jaundice

Bibliographic details Study type & Patient characteristics Test, Reference Standard, Results Reviewers Comments
Evidence level Threshold for a positive test
at the forehead and the sternum Sensitivity: 98%
In second phase (n = 1394), TcB and lab (mean of 3 measurements recorded Specificity: 72%
TSB values obtained to find accuracy of at each site used for analysis)
TSB and TcB at 24hours and 48 hours to Diagnostic accuracy for predicting
predict hyperbilirubinaemia. Reference standard: Laboratory TSB = 290 micromol/litre
TSB measured on Day 3 - 4
Prevalence of TSB > Prevalence of TSB = 290 micromol/litre
290 micromol/litre = 2.9% in phase 1 TSB = 290 micromol/litre taken as 2.9% in phase 1 (18/610) and 3.25% in
(18/610) and 3.25% in phase 2 (46/1324) indicative of phase 2 (46/1324)
hyperbilirubinaemia
Exclusion: not defined 1. For UCB
(threshold = 37 micromol/litre)
Sensitivity: 4/18 (22.2%)
Specificity: 537/567 (94.7%)
PPV: 4/34 (11.7%)
NPV: 537/551 (97.4%)

2. At 24 hours
For TcB in phase 1 (threshold > 11
Reflectance Units)
Sensitivity: 15/18 (83.3%)
Specificity: 368/556 (66.2%)
PPV: 15/203 (7.4%)
NPV: 368/371 (99.2%)

For TSB in phase 1
(threshold = 102 micromol/litre)
Sensitivity: 7/7 (100%)
Specificity: 74/162 (45.7%)
PPV: 7/95 (7.4%)
NPV:74/74 (100%)

For TSB in phase 2
(threshold = 102 micromol/litre)
Sensitivity: 25/25 (100%)
Specificity: 239/398 (60%)
PPV: 25/95 (26.3%)
NPV: 239/239 (100%)

2. At 48 hours
For TcB in phase 1 (threshold > 13
reflectance units)
Sensitivity: 17/18 (94.4%)
Specificity: 288/556 (51.7%)
PPV:
NPV:

For TcB in phase 2 (threshold > 13

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