Page 316 - 16Neonatal Jaundice_compressed

Appendix H: Evidence tables

Bibliographic details Study type & Patient characteristics Test, Reference Standard, Results Reviewers Comments
Evidence level Threshold for a positive test
reflectance units)
Sensitivity: 45/46 (97.8%)
Specificity: 262/819 (32.0%)
PPV: 45/602 (7.5%)
NPV: 262/263 (99.6%)

For TSB in phase 1
(threshold = 154 micromol/litre)
Sensitivity: 11/11 (100%)
Specificity: 102/158 (64.6%)
PPV: 11/67 (16.4%)
NPV: 101/102 (100%)

For TSB in phase 2
(threshold = 154 micromol/litre)
Sensitivity: 45/46 (97.8%)
Specificity: 348/774 (45%)
PPV: 45/471 (9.5%)
NPV: 348/349 (99.7%)

Knudsen A; Study Type: Babies in a newborn nursery were Test: Correlation of TcB levels with TSB levels Unselected population
Diagnostic study eligible if a visible jaundice was noted in TcB reading from the forehead (Pearson correlation coefficient, n = 76) Test & Reference test not
Year: 1989 first 5 days of life using JM-102 described in detail
Evidence Forehead Test and reference test carried
Country: Denmark Level:III n = 76, Reference standard: r = 0.83; P < 0.0001 out within one hour
Mean BW: Not reported Laboratory TSB method measured Blinding – not specified
70 Median GA: Not reported on blood collected at the same time
Gender: Not reported as TcB. No demographic details
Ethnicity: reported
Not reported

Exclusion:
None

Karrar Z; Study Type: Healthy term babies with visible jaundice TcB using Minolta JM-101 on the Correlation of TcB levels with lab TSB Unselected population
Diagnostic study aged between 4 and 10 days. forehead – single measurement levels (Pearson correlation coefficient, Test & Reference test not
Year: 1989 made n = 155) described in detail
Evidence Level: n = 155 Test and reference test carried
Country: III Mean BW: Not reported Reference standard: Laboratory r = 0.82, P < 0.01 out within one hour
Saudi Arabia Mean GA: Not reported TSB levels at the same time as TcB Blinding – not specified
Gender: Not reported measured Diagnostic accuracy of TcB (threshold value
69 > 21 reflectance units) for detecting TSB >
Ethnicity 214 micromol/litre
Saudi 100%
Sensitivity: 36/49 (73.5%)
Prevalence of TSB > Specificity: 95/106 (89.6%)

231