Page 311 - 16Neonatal Jaundice_compressed

Neonatal jaundice

Bibliographic details Study type & Patient characteristics Test, Reference Standard, Results Reviewers Comments
Evidence level Threshold for a positive test
n = 96)
r = 0.78, P < 0.01

Diagnostic accuracy for detecting TSB
> 220 micromol/litre
Sensitivity: 100% (17/17)
Specificity: 48.1% (38/79)
PPV: 29.3% (17/58)
NPV: 100% (38/38)

Merritt KA; Study Type: Preterm babies with jaundice in a 1) Gosset Icterometer on the nose Correlation of TcB levels with lab TSB Selected population
Diagnostic study hospital. by two experienced and one levels (Pearson correlation coefficient, Test & Reference test described
Year: 1994 inexperienced observer n = number of observations) in detail
Evidence Level: n = 90 Test and reference test carried
Country: II mean BW 1676 g, mean GA 31.7 weeks Reference standard: Laboratory All infants (n = 296) out within one hour
USA age at presentation: Not reported TSB levels within 30 min r = 0.72, P < 0.01 Blinding – yes
Gender: Not reported Data not extractable for
65 Experienced observer 1 (n = 239) calculating values of TP, FP,
Ethnicity r = 0.71, P < 0.01 TN & FN
White = 95%
Other = 5% Experienced observer 2 (n = 166)
r = 0.75, P < 0.01
Exclusion: not defined
Inexperienced observer
r = 0.63, P < 0.01

Hamel BCJ; Study Type: Newborn babies with clinical jaundice Gosset Icterometer reading by Correlation of Icterometer readings with lab Unselected population
Diagnostic study admitted for various reasons to neonatal blanching the gum TSB levels (Pearson correlation coefficient) Test & Reference test not
Year: 1982 unit of a medical centre described in detail
Evidence Level: Reference standard: Blood drawn r = 0.91, P < 0.01 Test and reference test carried
Country: III n = 70 for laboratory TSB levels at the out simultaneously (exact
Tanzania Mean BW: Not reported same time timing not specified)
GA: Range 30 to 42 weeks Blinding – not specified
64 Postnatal age: Range 2 to 14 days Data not extractable for
Gender: Not reported calculating values of TP, FP,
TN & FN
Ethnicity:
Black = 100%

Exclusion: not defined

Chaibva NT; Study Type: Newborn babies with clinical jaundice Gosset Icterometer reading (site not Correlation of Icterometer readings with lab Unselected population
Diagnostic study specified) TSB levels (Pearson correlation coefficient) Test & Reference test not
Year: 1974 n = 55 infants and 125 readings described in detail
Evidence Level: Reference standard: Laboratory r = 0.96, P < 0.001 Test and reference test carried
Country: III BW: Range 1050 to 3925 g TSB levels (timing not specified) out at same time (exact timing

228