Page 323 - 16Neonatal Jaundice_compressed

Neonatal jaundice

Bibliographic details Study type & Patient characteristics Test, Reference Standard, Results Reviewers Comments
Evidence level Threshold for a positive test

Difference > 68 micromol/litre
White – 0%
Black – 6.7%
Others – 1.1%

Schmidt ET et al.; Study Type: Convenience sample of newborn babies TcB using Minolta JM-103 from Correlation of TcB levels with lab TSB Test & Reference test described
Diagnostic study < 34 weeks in a NICU of 1 hospital. the sternum, and included a single levels adequately
Year: 2009 determination and a device – All groups
Evidence Level: n = 90 calculated mean of 5 R = 0.88, P < 0.001 Test and reference test carried
Country: II Range of BW: 370 – 2989 g determinations out within one hour
USA Range GA: 24 – 34 weeks TCB was carried out within 45 Group 1 GA 24 – 28 weeks
Gender: Males = 56.7% minutes of TSB./ r = 0.92 Blinding – not specified
73
Ethnicity Reference standard: Group 2 GA 29 – 31 weeks
white = 11.1% Laboratory TSB levels r = 0.90
black = 18.9%
hispanic = 70.0% Sensitivity and specific of TCB Group 3 GA 32 –34 weeks
> 68, 103, 137 micromol/litre r = 0.79

Exclusion: Bland-Altman analysis for mean difference
Hydrops fetalis between TCB and TSB
Severe haemolytic disease Group 1 GA 24 – 28 weeks
Non-viable -19 ± 32 micromol/l
Had receive or were receiving
phototherapy or an exchange transfusion Group 2 GA 29 – 31 weeks
-14 ± 22 micromol/litre

Group 3 GA 32 –34 weeks
-17 ± 27 micromol/litre

Engle WD; Study Type: Term and near term neonates who had TcB using Minolta JM-103 from Correlation of TcB levels with lab TSB Exclusion criterion not defined
Diagnostic study been discharged from the hospital and the sternum – single measurements levels (Pearson correlation coefficient, Test & Reference test described
Year: 2005 evaluated during first week postnatally in taken. n = 121) adequately
Evidence Level: a follow-up centre. Test and reference test carried
Country: II Reference standard: r = 0.77, P < 0.001 out within one hour
USA n = 121 Laboratory TSB levels within 30 Blinding – not specified
median BW: 3280 g – range 2265 to minutes of TcB measurement Bland Altman analysis for difference
72 4590 between TSB and TcB
median GA: 40 weeks – range 35 to 41 Diagnostic accuracy of TcB
median age at TSB: 91 hours – range 51 (various thresholds) calculated for MD = 27 micromol/litre
to 166 detecting TSB > 255, > 272, > 290
Gender: Males = 56.2%) and > 306 micromol/litre Diagnostic accuracy of TcB (threshold value
> 205 micromol/litre for detecting TSB >
Ethnicity 255 micromol/litre

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