Page 67 - LECTURE NOTES

Beau lines, telogen effluvium, and pallor of the nail beds are the general effects of the

chronic illness.

Proximal subungual onychomycosis is usually a sign of HIV disease

HIV-associated malignancies

Kaposi sarcoma: - KS was the first reported malignancy in association with HIV
infection.

The worldwide incidence of KS in patients with AIDS may approach 34%. KS is
believed to be a proliferation of endothelial cells induced by human herpesvirus type 8

(HHV-8).

KS begins as pink macules that become disseminated and palpable. Purplish or brown

macules and plaques may become nodular. Mucosal involvement is common.

The clinical progression of KS in patients infected with HIV is more aggressive than

the other clinical types of KS.

AIDS-related B-cell non-Hodgkin lymphomas may lead to skin nodules.

Anal carcinoma and cervical intraepithelial neoplasia (CIN) are papillomavirus-

associated tumors associated with HIV disease. These tumors tend to be more
progressive and aggressive.

N.B: Regarding Leprosy you are advised to refer the Manual prepared by disease
prevention and control department, Ministry of Health, Ethiopia, 2002. Also

encouraged to read modules prepared through EPHTI by member institutions for skin
manifestations of Onchocerciasis and leishmaniasis.

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