Page 66 - LECTURE NOTES

nephritis. Toxic epidermal necrolysis has been reported with antibiotics, fluconazole,

clindamycin, phenobarbital, and chlormezanone in patients with HIV.

Drug eruptions have been reported as the most common cause of erythroderma in
patients infected with HIV.

Photosensitivity has been reported in patients with advanced HIV disease. Photo-

induced lichenoid drug reactions may be seen particularly in dark-skinned patients.

Aphthosis:- Severe aphthous stomatitis may be associated with HIV disease.
Autoimmunity, atopic disease, and urticaria

Thrombocytopenic purpura, vitiligo, alopecia areata, sicca syndrome, pemphigoid, and
other autoimmune blistering diseases have been reported in association with HIV

disease.

Atopic disease may be reactivated by HIV disease. Atopic eczema may be severe in

children infected with HIV. Increased serum IgE levels have been found in these
children. However, increased IgE levels were not correlated with atopic symptoms.

Urticaria may occur primarily or as a drug eruption in HIV disease.

Photosensitivity has been reported in patients with advanced HIV disease. Photo-

induced lichenoid drug reactions may be seen particularly in dark-skinned patients.

Hair and nail disorders

Diffuse alopecia or alopecia areata may be associated with HIV disease and may be

inflammatory and permanent.

Generalized alopecia can occur in patients with HIV who are treated with indinavir, an

antiretroviral protease inhibitor.

Elongation of the eyelashes and softening and straightening of the scalp hair may be
observed in HIV disease.

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