Page 36 - LECTURE NOTES

Etiologic Agents: - Herpesvirus hominis

HSV 1 and HSV 2 50% homology

HSV 1 – orolabial herpes (commoner), 50% give Hx of lesions
HSV 2 – genital herpes (herpes progenitalis) -20% are asymptomatic

-20% have recurrent genital ulcer

-60% subclinical (unrecognizable)

Mode of Transmission:

HSV 1 - Oral secretions or directly from the lesions

HSV 2 – Sexual contact after sexual activity is started

- Through birth canal neonatal infection
- May imply child abuse if it is found in children

HSV 1 and HSV 2 can infect and reactivate the same anatomical area.

3.8.4. Pathogenesis:

HPV at Multiplication/

mucosal/abrad Entry of the Attachment Replication in
ed skin surface virus to cells the nucleus

Ascending of the
Multiplication
and spread to virus Discharged Cytopathic
transaxonally to effect on cells
other nerves virions
the sensory /
Autonomic
ganglion

Resolution of
Reactivation
the primary Latency
infection

Fig 1. Pathogenesis of herpes simplex virus

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